SMAD1 and RAB38

Number of citations of the paper that reports this interaction (PubMedID 15761153)
246

Data Source:
HPRD (in vivo)

		SMAD1	RAB38
Description		SMAD family member 1	RAB38, member RAS oncogene family
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GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nuclear Inner Membrane Nucleoplasm Transcription Factor Complex Cytoplasm Cytosol Integral Component Of Membrane Protein-containing Complex SMAD Protein Complex	Cell Mitochondrion Lysosome Early Endosome Endoplasmic Reticulum Trans-Golgi Network Cytosol Plasma Membrane Endomembrane System Membrane Phagocytic Vesicle Membrane Early Endosome Lumen Melanosome Membrane Melanosome Mitochondria-associated ER Membrane Phagocytic Vesicle
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding DEAD/H-box RNA Helicase Binding Protein Kinase Binding Transforming Growth Factor Beta Receptor, Pathway-specific Cytoplasmic Mediator Activity Identical Protein Binding Metal Ion Binding Co-SMAD Binding I-SMAD Binding Primary MiRNA Binding	GTPase Activity Protein Binding GTP Binding GTP-dependent Protein Binding AP-2 Adaptor Complex Binding AP-1 Adaptor Complex Binding AP-3 Adaptor Complex Binding BLOC-2 Complex Binding
	Biological Process	MAPK Cascade Ureteric Bud Development Mesodermal Cell Fate Commitment Osteoblast Fate Commitment Inflammatory Response Signal Transduction Transforming Growth Factor Beta Receptor Signaling Pathway SMAD Protein Complex Assembly Gamete Generation Negative Regulation Of Cell Proliferation Embryonic Pattern Specification Positive Regulation Of Gene Expression Protein Deubiquitination BMP Signaling Pathway Midbrain Development Hindbrain Development Primary MiRNA Processing Homeostatic Process Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Cartilage Development Cardiac Muscle Cell Proliferation Bone Development SMAD Protein Signal Transduction Positive Regulation Of Cartilage Development Cellular Response To Organic Cyclic Compound Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Cellular Response To Chemical Stimulus Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of Sprouting Angiogenesis	Intracellular Protein Transport Mitochondrion Organization Small GTPase Mediated Signal Transduction Protein Transport Vesicle-mediated Transport Melanosome Organization Rab Protein Signal Transduction Endosome To Melanosome Transport Post-translational Protein Modification Platelet Dense Granule Organization Protein Localization To Membrane Phagosome Acidification Melanosome Assembly Positive Regulation Of Phosphatidylcholine Biosynthetic Process
Pathways		Signaling by BMP Ub-specific processing proteases RUNX2 regulates bone development	RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs
Diseases
GWAS		Lung function (FEV1) ( 30061609) Midgestational cytokine/chemokine levels (maternal genetic effect) ( 30134952) Panic disorder ( 31712720) Response to cognitive-behavioural therapy in anxiety disorder ( 26989097)	Chloride levels ( 29403010) Frontotemporal dementia ( 24943344) Gut microbiota (bacterial taxa) ( 27694959) Multiple sclerosis (age of onset) ( 19010793) Sodium levels ( 29403010) Triiodothyronine levels ( 30824882) Urinary albumin-to-creatinine ratio in diabetes ( 26631737)
Interacting Genes		142 interacting genes: ACVR1 ACVRL1 AKR1B1 ANKRD27 AP2A2 APP AR ARHGEF6 ARL4D BMPR1A BTBD2 BTG2 CAMSAP1 CDK7 CDK9 CHMP3 CILK1 COL4A1 DACH1 DNMT3L DVL1 ECSIT EIF2AK4 ELP3 EP300 ERBIN EWSR1 FBXL12 FBXO30 FHL5 FOXG1 FRZB GDF6 GLI3 GMEB1 GSC HBP1 HIPK2 HOXA13 HOXA5 HOXC8 HOXD13 ING2 INPP4A IRF2BP1 KAT2B KMT2D LEF1 LEMD3 LMNA MAP2K3 MAPK1 MAST4 MBD1 MECOM MED6 MEN1 MGA MRTFB NAT9 NEDD4 NEDD9 NEUROG1 NKX3-2 NOTCH2 OAZ1 OAZ3 PAK1 PARD3 PIAS1 PIAS4 PIGQ PLEKHB1 PREB PSMB4 PSMD1 PSMD11 PUM1 RAB2B RAB30 RAB34 RAB38 RAB3B RAB6B RAC2 RAN RAP2A RASD2 RASL12 RFX1 RHEBL1 RHOG RPS27A SF3B1 SKI SKIL SMAD2 SMAD3 SMAD4 SMAD5 SMAD6 SMARCE1 SMURF1 SMURF2 SNIP1 SNRNP70 SOX5 SQSTM1 SS18L1 STARD13 STK11 STUB1 SUV39H1 TCF20 TGFBR1 TNNT1 TOB1 TRIP6 TTF1 TTF2 UBA52 UBC UBE2Z UBXN1 USP45 VEPH1 WDR77 XPC XPO1 YAP1 YY1 ZBTB44 ZDHHC3 ZEB2 ZNF251 ZNF423 ZNF510 ZNF512B ZNF521 ZNF76 ZNF8 ZSCAN4	7 interacting genes: APP BMPR1B SMAD1 SMAD2 SMAD3 SMAD4 TGFBR1
Entrez ID		4086	23682
HPRD ID		03356	05889
Ensembl ID		ENSG00000170365	ENSG00000123892
Uniprot IDs		Q15797	A0A024R191 P57729
PDB IDs		1KHU 2LAW 2LAX 2LAY 2LAZ 2LB0 2LB1 3Q47 3Q4A 5ZOK	6HDU
Enriched GO Terms of Interacting Partners?
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