AGTR1 and PDE6H

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		AGTR1	PDE6H
Description		angiotensin II receptor type 1	phosphodiesterase 6H
Image			No pdb structure
GO Annotations	Cellular Component	Cell Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane	Photoreceptor Outer Segment Membrane
	Molecular Function	Angiotensin Type I Receptor Activity G Protein-coupled Receptor Activity Angiotensin Type II Receptor Activity Protein Binding Bradykinin Receptor Binding Protein Heterodimerization Activity	Enzyme Inhibitor Activity Protein Binding CGMP Binding 3',5'-cyclic-GMP Phosphodiesterase Activity
	Biological Process	Regulation Of Cell Growth Kidney Development Renin-angiotensin Regulation Of Aldosterone Production Regulation Of Blood Vessel Diameter By Renin-angiotensin Regulation Of Systemic Arterial Blood Pressure By Renin-angiotensin Inflammatory Response G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Rho Protein Signal Transduction Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Esterification Regulation Of Vasoconstriction Calcium-mediated Signaling Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Phospholipase A2 Activity Positive Regulation Of NAD(P)H Oxidase Activity Low-density Lipoprotein Particle Remodeling Regulation Of Renal Sodium Excretion Angiotensin-activated Signaling Pathway Regulation Of Cell Proliferation Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Cell Chemotaxis Phospholipase C-activating Angiotensin-activated Signaling Pathway Regulation Of Blood Vessel Diameter Positive Regulation Of Blood Vessel Endothelial Cell Proliferation Involved In Sprouting Angiogenesis Positive Regulation Of Reactive Oxygen Species Metabolic Process	Activation Of MAPK Activity Visual Perception Negative Regulation Of Catalytic Activity Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Response To Stimulus
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs		Valsartan Olmesartan Losartan Candesartan cilexetil Eprosartan Telmisartan Irbesartan Forasartan Saprisartan Tasosartan CYT006-AngQb Azilsartan medoxomil Fimasartan Candesartan	Sildenafil Vardenafil
Diseases		Renal tubular dysgenesis	Cone-rod dystrophy and cone dystrophy, including: Cone-rod dystrophy (CORD); Cone dystrophy (COD); Retinal cone dystrophy (RCD)
GWAS		Birth weight ( 31043758) Chin dimples ( 27182965) Height ( 31562340) Lead levels in blood ( 25820613) Monobrow ( 27182965) Type 2 diabetes ( 31049640)
Interacting Genes		21 interacting genes: ACADM AGT AGTRAP ARRB1 ARRB2 BDKRB2 DNAJC14 EGFR GPRASP1 GRK2 GRK3 GRK5 HRAS JAK2 NOS3 PDE6H PLCG1 PTGFR RAB5A RAF1 THOP1	4 interacting genes: AGTR1 APP COTL1 GNAO1
Entrez ID		185	5149
HPRD ID		00107	03116
Ensembl ID		ENSG00000144891	ENSG00000139053
Uniprot IDs		A0A0A0MSE3 D3DNG8 P30556 Q53YY0 Q6NUP5	Q13956
PDB IDs		1ZV0 4YAY 4ZUD 6DO1
Enriched GO Terms of Interacting Partners?
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