LPL and VLDLR

Number of citations of the paper that reports this interaction (PubMedID 7592875)
30

Data Source:
BioGRID (pull down)
HPRD (in vitro)

		LPL	VLDLR
Description		lipoprotein lipase	very low density lipoprotein receptor
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Very-low-density Lipoprotein Particle Chylomicron	Lysosomal Membrane Plasma Membrane Clathrin-coated Pit Membrane Integral Component Of Membrane Very-low-density Lipoprotein Particle Receptor Complex
	Molecular Function	Lipoprotein Lipase Activity Phospholipase Activity Triglyceride Lipase Activity Signaling Receptor Binding Calcium Ion Binding Protein Binding Heparin Binding Lipase Activity Triglyceride Binding Apolipoprotein Binding Protein Homodimerization Activity Heparan Sulfate Proteoglycan Binding Protein Membrane Anchor Lipoprotein Particle Binding	Low-density Lipoprotein Particle Receptor Activity Calcium Ion Binding Protein Binding Very-low-density Lipoprotein Particle Receptor Activity Apolipoprotein Binding Very-low-density Lipoprotein Particle Binding Cargo Receptor Activity Reelin Receptor Activity Calcium-dependent Protein Binding
	Biological Process	Retinoid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Triglyceride Metabolic Process Phospholipid Metabolic Process Response To Cold Response To Bacterium Response To Glucose Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Positive Regulation Of Cholesterol Storage Positive Regulation Of Sequestering Of Triglyceride Lipid Catabolic Process Triglyceride Biosynthetic Process Triglyceride Catabolic Process Cellular Response To Nutrient Chylomicron Remodeling Very-low-density Lipoprotein Particle Remodeling Response To Drug Cholesterol Homeostasis Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Inflammatory Response Regulation Of Lipoprotein Lipase Activity Low-density Lipoprotein Particle Mediated Signaling Triglyceride Homeostasis Cellular Response To Fatty Acid Positive Regulation Of Chemokine Secretion Negative Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Chemokine (C-C Motif) Ligand 2 Secretion Positive Regulation Of Tumor Necrosis Factor Secretion Positive Regulation Of Interleukin-6 Secretion	Lipid Transport Receptor-mediated Endocytosis Signal Transduction Nervous System Development Axon Guidance Memory Cholesterol Metabolic Process Ventral Spinal Cord Development Low-density Lipoprotein Particle Receptor Catabolic Process Glycoprotein Transport Very-low-density Lipoprotein Particle Clearance Reelin-mediated Signaling Pathway Positive Regulation Of Protein Kinase Activity Dendrite Morphogenesis Positive Regulation Of Dendrite Development
Pathways		Transcriptional regulation of white adipocyte differentiation Assembly of active LPL and LIPC lipase complexes Chylomicron remodeling Retinoid metabolism and transport	Reelin signalling pathway VLDLR internalisation and degradation VLDL clearance
Drugs		Tyloxapol	Lauric Acid
Diseases		Hyperlipoproteinemia, type I
GWAS		Body mass index (adult) ( 28430825) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Cardiovascular disease risk factors ( 21943158) Cholesterol efflux capacity ( 30369316) Coronary artery disease ( 29212778 24262325 30104761) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diffusing capacity of carbon monoxide ( 30694715) Gut microbiota (beta diversity) ( 27723756) HDL cholesterol ( 23726366 24097068 20031538 21909109 28270201 24507774 18193043 18193044 20864672 26160806 19060906 19060911 21347282 25961943 26780889 20686565 26582766) HDL Cholesterol - Triglycerides (HDLC-TG) ( 21386085) HDL cholesterol levels ( 31694877 28334899 26763881 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Hematological and biochemical traits ( 20139978) High density lipoprotein cholesterol levels ( 30718733 30911093 29403010 29615537 28548082) Hyperactive-impulsive symptoms ( 18821565) Hypertriglyceridemia ( 23505323 20657596) Lipid metabolism phenotypes ( 22286219 19936222) Lipid traits ( 24386095 24023261) Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643) Medication use (antithrombotic agents) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 22399527 30382898 21386085 20694148 31589552) Metabolic syndrome (bivariate traits) ( 21386085) Metabolic syndrome (multivariate analysis) ( 29632305) Metabolic traits ( 19060910) Metabolite levels ( 22916037) Metabolite levels (lipoprotein measures) ( 27005778) Peripheral artery disease ( 31285632) Pulse pressure ( 27841878) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Susceptibility to persistent hepatitis B virus infection ( 27244555) Systolic blood pressure ( 27841878) Total triglycerides levels ( 29084231) Triacylglyceride levels ( 31551469) Triglyceride levels ( 30718733 28334899 26763881 30911093 29403010 29615537 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels in small VLDL ( 29084231) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglyceride to HDL cholesterol ratio ( 28046027) Triglycerides ( 23726366 24097068 21909109 24507774 18193043 18193044 18193046 20864672 26160806 19060906 19060911 24886709 22171074 20139978 17463246 25961943 20686565 26582766) Triglycerides-Blood Pressure (TG-BP) ( 21386085) Type 2 diabetes ( 30054458 30297969 29632382) Type 2 diabetes (adjusted for BMI) ( 29632382) Waist circumference and related phenotypes ( 18454146)	Alzheimer's disease (age of onset) ( 22005931) Cholesterol, total ( 24097068) Cytokine levels ( 31679650) Cytokine network levels (multivariate analysis) ( 31679650) Gambling ( 22780124) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) LDL cholesterol ( 24097068 30275531) LDL cholesterol levels ( 28334899) Systolic blood pressure ( 26969751) Total cholesterol levels ( 30275531) Vascular endothelial growth factor levels ( 26910538 27989323 31217265 21757650) White coat effect (clinic diastolic blood pressure minus ambulatory diastolic blood pressure) ( 31044621)
Interacting Genes		17 interacting genes: APOC2 APP ASCC2 CALR CCND1 CEP126 CETP COPS6 EMD LRP1 LRP2 LUC7L2 PTPN4 RPL18A TSC22D2 UBE2Z VLDLR	9 interacting genes: APOE CD36 CLU DAB1 LPL LRPAP1 MYLIP RELN SNX17
Entrez ID		4023	7436
HPRD ID		01999	01895
Ensembl ID		ENSG00000175445	ENSG00000147852
Uniprot IDs		A0A1B1RVA9 P06858	P98155 Q5VVF5
PDB IDs		6E7K 6OAU 6OAZ 6OB0	1V9U 3DPR 6BYV
Enriched GO Terms of Interacting Partners?
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