LPL and LRP1

Number of citations of the paper that reports this interaction (PubMedID 1281473)
19

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		LPL	LRP1
Description		lipoprotein lipase	LDL receptor related protein 1
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Cell Surface Very-low-density Lipoprotein Particle Chylomicron	Cell Nucleus Lysosomal Membrane Early Endosome Cytoskeleton Plasma Membrane Integral Component Of Plasma Membrane Clathrin-coated Pit Focal Adhesion Membrane Basolateral Plasma Membrane Clathrin-coated Vesicle Dendrite Endocytic Vesicle Membrane Insulin-responsive Compartment Neuronal Cell Body Receptor Complex Axonal Growth Cone Apical Part Of Cell Plasma Membrane Protein Complex Postsynaptic Golgi Apparatus
	Molecular Function	Lipoprotein Lipase Activity Phospholipase Activity Triglyceride Lipase Activity Signaling Receptor Binding Calcium Ion Binding Protein Binding Heparin Binding Lipase Activity Triglyceride Binding Apolipoprotein Binding Protein Homodimerization Activity Heparan Sulfate Proteoglycan Binding Protein Membrane Anchor Lipoprotein Particle Binding	Amyloid-beta Binding Protease Binding RNA Binding Low-density Lipoprotein Particle Receptor Activity Scavenger Receptor Activity Calcium Ion Binding Protein Binding Coreceptor Activity Alpha-2 Macroglobulin Receptor Activity Apolipoprotein Receptor Activity Clathrin Heavy Chain Binding Apolipoprotein Binding Signaling Receptor Activity Cargo Receptor Activity Heparan Sulfate Proteoglycan Binding Protein-containing Complex Binding Lipoprotein Particle Receptor Binding
	Biological Process	Retinoid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Triglyceride Metabolic Process Phospholipid Metabolic Process Response To Cold Response To Bacterium Response To Glucose Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Lipid Storage Positive Regulation Of Cholesterol Storage Positive Regulation Of Sequestering Of Triglyceride Lipid Catabolic Process Triglyceride Biosynthetic Process Triglyceride Catabolic Process Cellular Response To Nutrient Chylomicron Remodeling Very-low-density Lipoprotein Particle Remodeling Response To Drug Cholesterol Homeostasis Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Interleukin-1 Beta Secretion Positive Regulation Of Inflammatory Response Regulation Of Lipoprotein Lipase Activity Low-density Lipoprotein Particle Mediated Signaling Triglyceride Homeostasis Cellular Response To Fatty Acid Positive Regulation Of Chemokine Secretion Negative Regulation Of Cellular Response To Insulin Stimulus Positive Regulation Of Chemokine (C-C Motif) Ligand 2 Secretion Positive Regulation Of Tumor Necrosis Factor Secretion Positive Regulation Of Interleukin-6 Secretion	Retinoid Metabolic Process Astrocyte Activation Involved In Immune Response Lipid Metabolic Process Receptor-mediated Endocytosis Phagocytosis Lysosomal Transport Positive Regulation Of Cytosolic Calcium Ion Concentration Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Aging Cell Proliferation Regulation Of Extracellular Matrix Disassembly Positive Regulation Of Cholesterol Efflux Positive Regulation Of Cell Death Negative Regulation Of Neuron Projection Development Negative Regulation Of Smooth Muscle Cell Migration Cerebral Cortex Development Negative Regulation Of Wnt Signaling Pathway Receptor Internalization Positive Regulation Of Protein Binding Positive Regulation Of Lipid Transport Regulation Of Cholesterol Transport Regulation Of Phospholipase A2 Activity Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Aorta Morphogenesis Lipoprotein Metabolic Process Lipoprotein Transport Apoptotic Cell Clearance Negative Regulation Of Neuron Apoptotic Process Cellular Lipid Catabolic Process Transcytosis Positive Regulation Of Endocytosis Positive Regulation Of Axon Extension Involved In Regeneration Positive Regulation Of Collateral Sprouting Of Injured Axon Positive Regulation Of Phagocytosis Negative Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Focal Adhesion Assembly Chemoattraction Of Axon Positive Regulation Of ERK1 And ERK2 Cascade Amyloid-beta Clearance Amyloid-beta Clearance By Transcytosis Amyloid-beta Clearance By Cellular Catabolic Process Positive Regulation Of Schwann Cell Migration Positive Regulation Of Amyloid-beta Clearance Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Cholesterol Import Positive Regulation Of Chemokine (C-C Motif) Ligand 2 Secretion Positive Regulation Of Transcytosis Cellular Response To Amyloid-beta Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Metallopeptidase Activity Positive Regulation Of Lysosomal Protein Catabolic Process Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Pathways		Transcriptional regulation of white adipocyte differentiation Assembly of active LPL and LIPC lipase complexes Chylomicron remodeling Retinoid metabolism and transport	Scavenging of heme from plasma Retinoid metabolism and transport
Drugs		Tyloxapol	Antihemophilic factor, human recombinant Tenecteplase Coagulation Factor IX (Recombinant) Coagulation Factor IX Human
Diseases		Hyperlipoproteinemia, type I
GWAS		Body mass index (adult) ( 28430825) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Cardiovascular disease risk factors ( 21943158) Cholesterol efflux capacity ( 30369316) Coronary artery disease ( 29212778 24262325 30104761) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diffusing capacity of carbon monoxide ( 30694715) Gut microbiota (beta diversity) ( 27723756) HDL cholesterol ( 23726366 24097068 20031538 21909109 28270201 24507774 18193043 18193044 20864672 26160806 19060906 19060911 21347282 25961943 26780889 20686565 26582766) HDL Cholesterol - Triglycerides (HDLC-TG) ( 21386085) HDL cholesterol levels ( 31694877 28334899 26763881 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Hematological and biochemical traits ( 20139978) High density lipoprotein cholesterol levels ( 30718733 30911093 29403010 29615537 28548082) Hyperactive-impulsive symptoms ( 18821565) Hypertriglyceridemia ( 23505323 20657596) Lipid metabolism phenotypes ( 22286219 19936222) Lipid traits ( 24386095 24023261) Lipoprotein phospholipase A2 activity in cardiovascular disease ( 28753643) Medication use (antithrombotic agents) ( 31015401) Medication use (HMG CoA reductase inhibitors) ( 31015401) Metabolic syndrome ( 22399527 30382898 21386085 20694148 31589552) Metabolic syndrome (bivariate traits) ( 21386085) Metabolic syndrome (multivariate analysis) ( 29632305) Metabolic traits ( 19060910) Metabolite levels ( 22916037) Metabolite levels (lipoprotein measures) ( 27005778) Peripheral artery disease ( 31285632) Pulse pressure ( 27841878) Serum metabolite levels ( 31636271) Serum metabolite levels (CMS) ( 31636271) Susceptibility to persistent hepatitis B virus infection ( 27244555) Systolic blood pressure ( 27841878) Total triglycerides levels ( 29084231) Triacylglyceride levels ( 31551469) Triglyceride levels ( 30718733 28334899 26763881 30911093 29403010 29615537 30698716) Triglyceride levels in current drinkers ( 30698716) Triglyceride levels in small VLDL ( 29084231) Triglyceride levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Triglyceride levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535) Triglyceride levels x short total sleep time interaction (2df test) ( 31719535) Triglyceride to HDL cholesterol ratio ( 28046027) Triglycerides ( 23726366 24097068 21909109 24507774 18193043 18193044 18193046 20864672 26160806 19060906 19060911 24886709 22171074 20139978 17463246 25961943 20686565 26582766) Triglycerides-Blood Pressure (TG-BP) ( 21386085) Type 2 diabetes ( 30054458 30297969 29632382) Type 2 diabetes (adjusted for BMI) ( 29632382) Waist circumference and related phenotypes ( 18454146)	Abdominal aortic aneurysm ( 27899403 22055160) Adult asthma ( 30787307) Asthma ( 27182965 31619474 29273806) Asthma (adult onset) ( 31036433) Asthma (childhood onset) ( 31036433) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 31043756) Body mass index ( 28552196) Cervical artery dissection ( 25420145) Coronary artery disease ( 29212778) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) HDL cholesterol ( 24097068 20686565) HDL cholesterol levels ( 28334899) Headache ( 29397368) Height ( 31562340) Itch intensity from mosquito bite ( 28199695) Lung function (FEV1/FVC) ( 30804560) Medication use (anilides) ( 31015401) Medication use (antimigraine preparations) ( 31015401) Migraine ( 22683712 27182965 23793025 21666692 27322543) Migraine - clinic-based ( 23793025) Migraine without aura ( 23793025 27322543) Moyamoya disease ( 29273593) Peak expiratory flow ( 30804560) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Pulse pressure ( 30578418) Schizophrenia ( 25056061 29483656) Triglyceride levels ( 28334899) Triglycerides ( 24097068 25961943 20686565)
Interacting Genes		17 interacting genes: APOC2 APP ASCC2 CALR CCND1 CEP126 CETP COPS6 EMD LRP1 LRP2 LUC7L2 PTPN4 RPL18A TSC22D2 UBE2Z VLDLR	66 interacting genes: A2M ANAPC10 ANKS1B APBA2 APBB1 APOE APP BACE1 C3 C4BPA CACNA1A CALR CANX CAV1 CC2D1A CCN2 CD82 CTSG DAB1 DAB2 DLG4 EGFR ELANE F8 F9 FURIN GIPC1 GTPBP1 GULP1 HNRNPDL HSP90B1 ITGB1BP1 KAT5 LIPC LPL LRPAP1 LTF MAPK8IP1 MAPK8IP2 MAPRE1 MDK MMP13 MMP14 MMP15 MMP16 MMP17 MTDH NOS1AP PDGFB PID1 PLAT PLAUR PRKACA PTPN11 RIC8B SCN3A SERPINA1 SERPINE1 SHC1 SKIL SNRNP70 SNX17 SRC SYNJ2BP THBS1 WNT3A
Entrez ID		4023	4035
HPRD ID		01999	00138
Ensembl ID		ENSG00000175445	ENSG00000123384
Uniprot IDs		A0A1B1RVA9 P06858	Q07954 Q59FG2
PDB IDs		6E7K 6OAU 6OAZ 6OB0	1CR8 1D2L 1J8E 2FYJ 2FYL 2KNX 2KNY
Enriched GO Terms of Interacting Partners?
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