VLDLR and RELN

Number of citations of the paper that reports this interaction (PubMedID 10571241)
235

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		VLDLR	RELN
Description		very low density lipoprotein receptor	reelin
Image			No pdb structure
GO Annotations	Cellular Component	Lysosomal Membrane Plasma Membrane Clathrin-coated Pit Membrane Integral Component Of Membrane Very-low-density Lipoprotein Particle Receptor Complex	Extracellular Region Extracellular Space Cytoplasm Plasma Membrane Dendrite Extracellular Matrix Neuron Projection
	Molecular Function	Low-density Lipoprotein Particle Receptor Activity Calcium Ion Binding Protein Binding Very-low-density Lipoprotein Particle Receptor Activity Apolipoprotein Binding Very-low-density Lipoprotein Particle Binding Cargo Receptor Activity Reelin Receptor Activity Calcium-dependent Protein Binding	Serine-type Peptidase Activity Metal Ion Binding Lipoprotein Particle Receptor Binding Very-low-density Lipoprotein Particle Receptor Binding
	Biological Process	Lipid Transport Receptor-mediated Endocytosis Signal Transduction Nervous System Development Axon Guidance Memory Cholesterol Metabolic Process Ventral Spinal Cord Development Low-density Lipoprotein Particle Receptor Catabolic Process Glycoprotein Transport Very-low-density Lipoprotein Particle Clearance Reelin-mediated Signaling Pathway Positive Regulation Of Protein Kinase Activity Dendrite Morphogenesis Positive Regulation Of Dendrite Development	Cell Morphogenesis Involved In Differentiation Neuron Migration Proteolysis Cell Adhesion Axon Guidance Central Nervous System Development Brain Development Long-term Memory Associative Learning Glial Cell Differentiation Positive Regulation Of Neuron Projection Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Dendrite Development Peptidyl-tyrosine Phosphorylation Spinal Cord Patterning Ventral Spinal Cord Development Hippocampus Development Cerebral Cortex Tangential Migration Layer Formation In Cerebral Cortex Positive Regulation Of TOR Signaling Positive Regulation Of CREB Transcription Factor Activity Reelin-mediated Signaling Pathway Positive Regulation Of Protein Kinase Activity Response To Pain Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Behavior Modulation Of Chemical Synaptic Transmission Positive Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Synaptic Transmission, Glutamatergic Long-term Synaptic Potentiation Positive Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Protein Tyrosine Kinase Activity Positive Regulation Of Synapse Maturation NMDA Glutamate Receptor Clustering Postsynaptic Density Protein 95 Clustering Receptor Localization To Synapse Lateral Motor Column Neuron Migration Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Lateral Motor Column Neuron Migration Regulation Of NMDA Receptor Activity Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of AMPA Receptor Activity
Pathways		Reelin signalling pathway VLDLR internalisation and degradation VLDL clearance	Reelin signalling pathway
Drugs		Lauric Acid
Diseases			Lissencephaly (LIS); Miller-Dieker syndrome (MDLS)
GWAS		Alzheimer's disease (age of onset) ( 22005931) Cholesterol, total ( 24097068) Cytokine levels ( 31679650) Cytokine network levels (multivariate analysis) ( 31679650) Gambling ( 22780124) Hematocrit ( 27863252) Hemoglobin concentration ( 27863252) LDL cholesterol ( 24097068 30275531) LDL cholesterol levels ( 28334899) Systolic blood pressure ( 26969751) Total cholesterol levels ( 30275531) Vascular endothelial growth factor levels ( 26910538 27989323 31217265 21757650) White coat effect (clinic diastolic blood pressure minus ambulatory diastolic blood pressure) ( 31044621)	Alzheimer's disease ( 20452100) Bitter alcoholic beverage consumption ( 31046077) Intraocular pressure ( 29785010) Metabolite levels (Pyroglutamine) ( 23934736) Morning person ( 30696823) Multiple sclerosis (age of onset) ( 19010793) Night sleep phenotypes ( 27126917) Otosclerosis ( 19230858) Response to placebo treatment in childhood asthma (FVC change) ( 31557306) Schizophrenia ( 18282107) SjÃ¶gren's syndrome ( 28076899) Sucrose liking ( 31005972) Type 2 diabetes ( 30054458 30297969) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		9 interacting genes: APOE CD36 CLU DAB1 LPL LRPAP1 MYLIP RELN SNX17	6 interacting genes: DAB1 LRP8 PCDHA4 PCDHA6 SQSTM1 VLDLR
Entrez ID		7436	5649
HPRD ID		01895	02742
Ensembl ID		ENSG00000147852	ENSG00000189056
Uniprot IDs		P98155 Q5VVF5	P78509
PDB IDs		1V9U 3DPR 6BYV
Enriched GO Terms of Interacting Partners?
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