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LRP1 and CALR
Number of citations of the paper that reports this interaction (PubMedID
12821648
)
56
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vivo)
LRP1
CALR
Description
LDL receptor related protein 1
calreticulin
Image
GO Annotations
Cellular Component
Cell
Nucleus
Lysosomal Membrane
Early Endosome
Cytoskeleton
Plasma Membrane
Integral Component Of Plasma Membrane
Clathrin-coated Pit
Focal Adhesion
Membrane
Basolateral Plasma Membrane
Clathrin-coated Vesicle
Dendrite
Endocytic Vesicle Membrane
Insulin-responsive Compartment
Neuronal Cell Body
Receptor Complex
Axonal Growth Cone
Apical Part Of Cell
Plasma Membrane Protein Complex
Postsynaptic Golgi Apparatus
Acrosomal Vesicle
Extracellular Region
Extracellular Space
Cell
Nucleus
Nuclear Envelope
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Lumen
Endoplasmic Reticulum Membrane
Smooth Endoplasmic Reticulum
Golgi Apparatus
Cytosol
Polysome
Focal Adhesion
External Side Of Plasma Membrane
Cell Surface
Membrane
Phagocytic Vesicle Membrane
Sarcoplasmic Reticulum Lumen
Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane
MHC Class I Peptide Loading Complex
Endoplasmic Reticulum Quality Control Compartment
Perinuclear Region Of Cytoplasm
Collagen-containing Extracellular Matrix
Extracellular Exosome
Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane
Endocytic Vesicle Lumen
Molecular Function
Amyloid-beta Binding
Protease Binding
RNA Binding
Low-density Lipoprotein Particle Receptor Activity
Scavenger Receptor Activity
Calcium Ion Binding
Protein Binding
Coreceptor Activity
Alpha-2 Macroglobulin Receptor Activity
Apolipoprotein Receptor Activity
Clathrin Heavy Chain Binding
Apolipoprotein Binding
Signaling Receptor Activity
Cargo Receptor Activity
Heparan Sulfate Proteoglycan Binding
Protein-containing Complex Binding
Lipoprotein Particle Receptor Binding
Complement Component C1q Binding
DNA Binding
RNA Binding
MRNA Binding
Integrin Binding
Iron Ion Binding
Calcium Ion Binding
Protein Binding
Zinc Ion Binding
Carbohydrate Binding
Ubiquitin Protein Ligase Binding
Peptide Binding
Hormone Binding
Protein Binding Involved In Protein Folding
Androgen Receptor Binding
Unfolded Protein Binding
Chaperone Binding
Biological Process
Retinoid Metabolic Process
Astrocyte Activation Involved In Immune Response
Lipid Metabolic Process
Receptor-mediated Endocytosis
Phagocytosis
Lysosomal Transport
Positive Regulation Of Cytosolic Calcium Ion Concentration
Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway
Aging
Cell Proliferation
Regulation Of Extracellular Matrix Disassembly
Positive Regulation Of Cholesterol Efflux
Positive Regulation Of Cell Death
Negative Regulation Of Neuron Projection Development
Negative Regulation Of Smooth Muscle Cell Migration
Cerebral Cortex Development
Negative Regulation Of Wnt Signaling Pathway
Receptor Internalization
Positive Regulation Of Protein Binding
Positive Regulation Of Lipid Transport
Regulation Of Cholesterol Transport
Regulation Of Phospholipase A2 Activity
Regulation Of Actin Cytoskeleton Organization
Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus
Aorta Morphogenesis
Lipoprotein Metabolic Process
Lipoprotein Transport
Apoptotic Cell Clearance
Negative Regulation Of Neuron Apoptotic Process
Cellular Lipid Catabolic Process
Transcytosis
Positive Regulation Of Endocytosis
Positive Regulation Of Axon Extension Involved In Regeneration
Positive Regulation Of Collateral Sprouting Of Injured Axon
Positive Regulation Of Phagocytosis
Negative Regulation Of Cytosolic Calcium Ion Concentration
Negative Regulation Of Focal Adhesion Assembly
Chemoattraction Of Axon
Positive Regulation Of ERK1 And ERK2 Cascade
Amyloid-beta Clearance
Amyloid-beta Clearance By Transcytosis
Amyloid-beta Clearance By Cellular Catabolic Process
Positive Regulation Of Schwann Cell Migration
Positive Regulation Of Amyloid-beta Clearance
Positive Regulation Of Protein Localization To Plasma Membrane
Positive Regulation Of Cholesterol Import
Positive Regulation Of Chemokine (C-C Motif) Ligand 2 Secretion
Positive Regulation Of Transcytosis
Cellular Response To Amyloid-beta
Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Negative Regulation Of Metallopeptidase Activity
Positive Regulation Of Lysosomal Protein Catabolic Process
Negative Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway
Negative Regulation Of Transcription By RNA Polymerase II
Antigen Processing And Presentation Of Peptide Antigen Via MHC Class I
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
Peptide Antigen Assembly With MHC Class I Protein Complex
Regulation Of Transcription, DNA-templated
Protein Folding
Protein Export From Nucleus
Cellular Calcium Ion Homeostasis
Receptor-mediated Endocytosis
Spermatogenesis
Positive Regulation Of Cell Proliferation
Positive Regulation Of Endothelial Cell Migration
Positive Regulation Of Gene Expression
Negative Regulation Of Translation
Protein Maturation By Protein Folding
Cortical Actin Cytoskeleton Organization
Endoplasmic Reticulum Unfolded Protein Response
Response To Estradiol
Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway
Response To Testosterone
Protein Localization To Nucleus
Protein Folding In Endoplasmic Reticulum
ATF6-mediated Unfolded Protein Response
Regulation Of Meiotic Nuclear Division
Response To Drug
Glucocorticoid Receptor Signaling Pathway
Regulation Of Apoptotic Process
Negative Regulation Of Neuron Differentiation
Positive Regulation Of Cell Cycle
Negative Regulation Of Transcription, DNA-templated
Negative Regulation Of Retinoic Acid Receptor Signaling Pathway
Positive Regulation Of Phagocytosis
Protein Stabilization
Sequestering Of Calcium Ion
Cardiac Muscle Cell Differentiation
Negative Regulation Of Cell Cycle Arrest
Cellular Response To Lithium Ion
Cellular Senescence
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Negative Regulation Of Trophoblast Cell Migration
Positive Regulation Of NIK/NF-kappaB Signaling
Vesicle Fusion With Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Membrane
Positive Regulation Of Dendritic Cell Chemotaxis
Pathways
Scavenging of heme from plasma
Retinoid metabolism and transport
ER-Phagosome pathway
Assembly of Viral Components at the Budding Site
Scavenging by Class A Receptors
Scavenging by Class A Receptors
Scavenging by Class F Receptors
Scavenging by Class F Receptors
ATF6 (ATF6-alpha) activates chaperone genes
Calnexin/calreticulin cycle
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Drugs
Antihemophilic factor, human recombinant
Tenecteplase
Coagulation Factor IX (Recombinant)
Coagulation Factor IX Human
Antihemophilic factor, human recombinant
Tenecteplase
Melatonin
Copper
Calcium Citrate
Calcium Phosphate
Diseases
GWAS
Abdominal aortic aneurysm (
27899403
22055160
)
Adult asthma (
30787307
)
Asthma (
27182965
31619474
29273806
)
Asthma (adult onset) (
31036433
)
Asthma (childhood onset) (
31036433
)
Autism spectrum disorder or schizophrenia (
28540026
)
Bipolar disorder (
31043756
)
Body mass index (
28552196
)
Cervical artery dissection (
25420145
)
Coronary artery disease (
29212778
)
Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) (
28714975
)
HDL cholesterol (
24097068
20686565
)
HDL cholesterol levels (
28334899
)
Headache (
29397368
)
Height (
31562340
)
Itch intensity from mosquito bite (
28199695
)
Lung function (FEV1/FVC) (
30804560
)
Medication use (anilides) (
31015401
)
Medication use (antimigraine preparations) (
31015401
)
Migraine (
22683712
27182965
23793025
21666692
27322543
)
Migraine - clinic-based (
23793025
)
Migraine without aura (
23793025
27322543
)
Moyamoya disease (
29273593
)
Peak expiratory flow (
30804560
)
Pulmonary function (
21946350
)
Pulmonary function (smoking interaction) (
23284291
)
Pulse pressure (
30578418
)
Schizophrenia (
25056061
29483656
)
Triglyceride levels (
28334899
)
Triglycerides (
24097068
25961943
20686565
)
Clozapine-induced agranulocytosis (
25187353
)
Estimated glomerular filtration rate (
31152163
)
Red blood cell traits (
23222517
)
Interacting Genes
66 interacting genes:
A2M
ANAPC10
ANKS1B
APBA2
APBB1
APOE
APP
BACE1
C3
C4BPA
CACNA1A
CALR
CANX
CAV1
CC2D1A
CCN2
CD82
CTSG
DAB1
DAB2
DLG4
EGFR
ELANE
F8
F9
FURIN
GIPC1
GTPBP1
GULP1
HNRNPDL
HSP90B1
ITGB1BP1
KAT5
LIPC
LPL
LRPAP1
LTF
MAPK8IP1
MAPK8IP2
MAPRE1
MDK
MMP13
MMP14
MMP15
MMP16
MMP17
MTDH
NOS1AP
PDGFB
PID1
PLAT
PLAUR
PRKACA
PTPN11
RIC8B
SCN3A
SERPINA1
SERPINE1
SHC1
SKIL
SNRNP70
SNX17
SRC
SYNJ2BP
THBS1
WNT3A
46 interacting genes:
APOB
APP
AR
B2M
CD1D
F5
F8
FBN1
FGB
HLA-A
HLA-C
HLA-E
ITGA2B
ITGA3
ITGAV
LPL
LRIF1
LRP1
MAPK6
MBL2
MTNR1A
NKX2-1
NR3C1
PDIA2
PDIA3
PLAT
PLP1
PRF1
PTPN11
RNY1
RNY3
RNY4
SCARF1
SIRPA
SLC2A1
SLC6A4
SMARCB1
SUMO4
TAPBP
TF
THBS1
TRIM21
TSHR
UBE3A
UPF2
VWF
Entrez ID
4035
811
HPRD ID
00138
00169
Ensembl ID
ENSG00000123384
ENSG00000179218
Uniprot IDs
Q07954
Q59FG2
P27797
V9HW88
PDB IDs
1CR8
1D2L
1J8E
2FYJ
2FYL
2KNX
2KNY
2CLR
3DOW
3POS
3POW
5LK5
5V90
6ENY
Enriched GO Terms of Interacting Partners
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