LIMS1 and PARVA

Number of citations of the paper that reports this interaction (PubMedID 12432066)
56

Data Source:
HPRD (in vivo, in vitro)

		LIMS1	PARVA
Description		LIM zinc finger domain containing 1	parvin alpha
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Z Disc Lamellipodium
	Molecular Function	Protein Binding Zinc Ion Binding Protein Kinase Binding	Actin Binding Protein Binding Cadherin Binding
	Biological Process	Epithelial To Mesenchymal Transition Cell Aging Positive Regulation Of Gene Expression Positive Regulation Of Cell-substrate Adhesion Tumor Necrosis Factor-mediated Signaling Pathway Cell Junction Assembly Positive Regulation Of GTPase Activity Establishment Of Protein Localization Cell-cell Junction Organization Negative Regulation Of Transcription, DNA-templated Regulation Of Epithelial Cell Proliferation Positive Regulation Of Focal Adhesion Assembly Cellular Response To Transforming Growth Factor Beta Stimulus Cell-cell Adhesion Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Integrin-mediated Signaling Pathway	Sprouting Angiogenesis Outflow Tract Septum Morphogenesis Establishment Or Maintenance Of Cell Polarity Regulation Of Cell Shape Cell Projection Assembly Actin Cytoskeleton Reorganization Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Cilium Assembly Actin-mediated Cell Contraction Smooth Muscle Cell Chemotaxis
Pathways		Cell-extracellular matrix interactions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components	Localization of the PINCH-ILK-PARVIN complex to focal adhesions Cell-extracellular matrix interactions Regulation of cytoskeletal remodeling and cell spreading by IPP complex components
Drugs
Diseases
GWAS		Beard thickness ( 26926045) Birth weight ( 31043758) Excessive hairiness ( 29895819) Eyebrow thickness ( 26926045) LDL cholesterol ( 30275531) Monobrow thickness ( 26926045) Scalp hair shape ( 26926045)	Depressive symptoms (SSRI exposure interaction) ( 25649181) Diisocyanate-induced asthma ( 25918132) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Lung adenocarcinoma ( 28604730) Mortality in heart failure ( 20400778)
Interacting Genes		14 interacting genes: DAPK1 EHMT2 FERMT2 FERMT3 ILK LPXN MBIP NCK2 PARVA RBBP8 RSU1 SMURF1 TGFBR1 TMSB4X	15 interacting genes: ACTA1 APP ERO1B FERMT1 FERMT2 FERMT3 HSPB2 ILK LIMS1 MAP2K1 MLH1 NFE2L1 PXN UBE3A UBQLN1
Entrez ID		3987	55742
HPRD ID		03978	16283
Ensembl ID		ENSG00000169756	ENSG00000197702
Uniprot IDs		P48059	Q9NVD7
PDB IDs		1G47 1NYP 1U5S 2COR 2D8X 2KBX 3F6Q 4HI8 4HI9 6MIF	2K2R 2VZC 2VZD 2VZG 2VZI 3KMU 3KMW 3REP 6MIB
Enriched GO Terms of Interacting Partners?
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