RPSA and TRIB3

Number of citations of the paper that reports this interaction (PubMedID 18276110)
13

Data Source:
BioGRID (two hybrid)

		RPSA	TRIB3
Description		ribosomal protein SA	tribbles pseudokinase 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Cytosolic Small Ribosomal Subunit Extracellular Exosome	Nucleus Nucleoplasm Cytosol Plasma Membrane
	Molecular Function	Virus Receptor Activity RNA Binding Structural Constituent Of Ribosome Laminin Receptor Activity Protein Binding Ribosome Binding Laminin Binding	Transcription Corepressor Activity Protein Kinase Inhibitor Activity Protein Binding ATP Binding Kinase Activity Protein Kinase Binding Mitogen-activated Protein Kinase Kinase Binding Ubiquitin Protein Ligase Binding Ubiquitin-protein Transferase Regulator Activity
	Biological Process	Ribosomal Small Subunit Assembly Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Cytoplasmic Translation Translation Translational Initiation SRP-dependent Cotranslational Protein Targeting To Membrane Cell Adhesion Viral Transcription Viral Entry Into Host Cell	Negative Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Negative Regulation Of Protein Kinase Activity Regulation Of Autophagy Regulation Of Glucose Transmembrane Transport Regulation Of Lipid Metabolic Process Positive Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Cellular Response To Insulin Stimulus Response To Endoplasmic Reticulum Stress Regulation Of MAP Kinase Activity Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Fatty Acid Biosynthetic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Protein Kinase B Signaling Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress
Pathways		L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)	PIP3 activates AKT signaling Activation of AKT2 PPARA activates gene expression Negative regulation of the PI3K/AKT network CD28 dependent PI3K/Akt signaling VEGFR2 mediated vascular permeability Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency
Drugs		Tigapotide Copper
Diseases
GWAS		Dentate gyrus volume x schizophrenia interaction ( 31155012)	Information processing speed ( 21130836) Logical memory (delayed recall) ( 29274321) Logical memory (immediate recall) ( 29274321)
Interacting Genes		28 interacting genes: ABCD1 ACADVL ACD ANKH CALM2 CBX5 CLEC4G CSF2RA DCTN6 GNMT HBG2 HNRNPD HSPB1 IL7R ILRUN ITGA6 KARS1 LAMA2 NKX3-1 POT1 PRND PROS1 RNF114 RPS21 SLC2A5 SUMO4 TINF2 TRIB3	28 interacting genes: AKT1 AKT2 APOBEC3A APOBEC3C APP ATF4 BMPR2 COPS6 DDIT3 EEF1G FBXO7 GDF9 GIT1 HLA-B KAT5 MDFI PML PRMT5 PSMA3 RARA RBM4 RBM48 RELA RIDA RPGRIP1 RPSA SETDB1 SQSTM1
Entrez ID		3921	57761
HPRD ID		01038	09836
Ensembl ID		ENSG00000168028	ENSG00000101255
Uniprot IDs		A0A024R2L6 A0A0C4DG17 P08865	B4DMM9 J3KR25 Q96RU7
PDB IDs		3BCH 4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6EK0 6FEC 6G18 6G4S 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP
Enriched GO Terms of Interacting Partners?
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