ALDH5A1 and ABAT

Number of citations of the paper that reports this interaction (PubMedID 6470007)
6

Data Source:
HPRD (in vitro)

		ALDH5A1	ABAT
Description		aldehyde dehydrogenase 5 family member A1	4-aminobutyrate aminotransferase
Image			No pdb structure
GO Annotations	Cellular Component	Mitochondrion Mitochondrial Matrix	Mitochondrion Mitochondrial Matrix 4-aminobutyrate Transaminase Complex Neuron Projection
	Molecular Function	Succinate-semialdehyde Dehydrogenase (NAD+) Activity Succinate-semialdehyde Dehydrogenase [NAD(P)+] Activity Identical Protein Binding	4-aminobutyrate Transaminase Activity Pyridoxal Phosphate Binding Succinate-semialdehyde Dehydrogenase Binding 4-aminobutyrate:2-oxoglutarate Transaminase Activity Identical Protein Binding Metal Ion Binding (S)-3-amino-2-methylpropionate Transaminase Activity Iron-sulfur Cluster Binding
	Biological Process	Glucose Metabolic Process Acetate Metabolic Process Succinate Metabolic Process Glutamate Metabolic Process Glutamine Metabolic Process Glycerophospholipid Metabolic Process Galactosylceramide Metabolic Process Glutathione Metabolic Process Central Nervous System Development Gamma-aminobutyric Acid Catabolic Process Post-embryonic Development Respiratory Electron Transport Chain Neurotransmitter Catabolic Process Short-chain Fatty Acid Metabolic Process	Response To Hypoxia Aging Copulation Locomotory Behavior Gamma-aminobutyric Acid Metabolic Process Gamma-aminobutyric Acid Biosynthetic Process Gamma-aminobutyric Acid Catabolic Process Response To Iron Ion Negative Regulation Of Gamma-aminobutyric Acid Secretion Cerebellum Development Positive Regulation Of Heat Generation Positive Regulation Of Insulin Secretion Negative Regulation Of Dopamine Secretion Response To Nicotine Exploration Behavior Neurotransmitter Catabolic Process Response To Ethanol Negative Regulation Of Blood Pressure Positive Regulation Of Dopamine Metabolic Process Behavioral Response To Cocaine Positive Regulation Of Uterine Smooth Muscle Contraction Negative Regulation Of Platelet Aggregation Positive Regulation Of Inhibitory Postsynaptic Potential Positive Regulation Of Prolactin Secretion Positive Regulation Of Aspartate Secretion
Pathways		Degradation of GABA	Degradation of GABA
Drugs		Succinic acid NADH Valproic Acid Chlormerodrin	Pyridoxal Phosphate Pyruvic acid Glutamic Acid L-Alanine Valproic Acid Phenelzine Vigabatrin (4e)-4-Aminohex-4-Enoic Acid 4-Amino Hexanoic Acid
Diseases		Succinic semialdehyde dehydrogenase (SSADH) deficiency; 4-Hydroxybutyric aciduria (4-HBA)
GWAS		Liver enzyme levels (alkaline phosphatase) ( 22001757)	Anger ( 24489884) Bronchopulmonary dysplasia in preterm infants ( 30113228) Menopause (age at onset) ( 26414677) Response to opioid analgesics in cancer (pain decrease) ( 30277654)
Interacting Genes		3 interacting genes: ABAT ARF6 MAGEA11	1 interacting genes: ALDH5A1
Entrez ID		7915	18
HPRD ID		08361	00661
Ensembl ID		ENSG00000112294	ENSG00000183044
Uniprot IDs		P51649 X5D299 X5DQN2	P80404 X5D8S1
PDB IDs		2W8N 2W8O 2W8P 2W8Q 2W8R
Enriched GO Terms of Interacting Partners?
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