NHLRC1 and EPM2A

Number of citations of the paper that reports this interaction (PubMedID 26546463)
6

Data Source:
BioGRID (pull down, affinity chromatography technology, two hybrid)

		NHLRC1	EPM2A
Description		NHL repeat containing E3 ubiquitin protein ligase 1	EPM2A glucan phosphatase, laforin
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Cytosol Perinuclear Region Of Cytoplasm	Nucleus
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Protein Polyubiquitination Glycogen Biosynthetic Process Autophagy Regulation Of Gene Expression Positive Regulation Of Protein Ubiquitination Response To Endoplasmic Reticulum Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Kinase Activity Regulation Of Protein Localization To Plasma Membrane	Positive Regulation Of Macroautophagy Negative Regulation Of TOR Signaling
Pathways		Glycogen synthesis Myoclonic epilepsy of Lafora	Glycogen synthesis Myoclonic epilepsy of Lafora
Drugs
Diseases		Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)	Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
GWAS		Intrinsic epigenetic age acceleration ( 29374233)	Loneliness (multivariate analysis) ( 27629369) Mean platelet volume ( 27863252) Methadone dose in opioid dependence ( 28115739) Response to mepolizumab in severe asthma ( 29229094)
Interacting Genes		9 interacting genes: AGL EPM2A GYS1 NNAT PPP1R3C UBE2D1 UBE2D3 UBE2E1 UBE2H	16 interacting genes: COX5A EIF2B1 EPM2AIP1 HMGXB4 NFU1 NHLRC1 PKM PPP1R3C PPP1R3D PRKAA1 PRKAA2 PRKAB2 PSMC3 SRPK2 TDG TOPORS
Entrez ID		378884	7957
HPRD ID		06995	06345
Ensembl ID		ENSG00000187566	ENSG00000112425
Uniprot IDs		Q6VVB1	H0UI04 O95278
PDB IDs			4R30 4RKK
Enriched GO Terms of Interacting Partners?
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