USP17L2 and SNAI1

Number of citations of the paper that reports this interaction (PubMedID 28067227)
31

Data Source:
BioGRID (enzymatic study)

		USP17L2	SNAI1
Description		ubiquitin specific peptidase 17 like family member 2	snail family transcriptional repressor 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Membrane Cytosol	Nucleus Nucleoplasm Pericentric Heterochromatin Cytoplasm Cytosol
	Molecular Function	Cysteine-type Endopeptidase Activity Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding Thiol-dependent Ubiquitinyl Hydrolase Activity	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Kinase Binding Metal Ion Binding E-box Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Mitotic Cell Cycle Checkpoint Negative Regulation Of Protein Processing Protein Deubiquitination Regulation Of Cell Migration Negative Regulation Of Histone Deacetylation Negative Regulation Of GTPase Activity Regulation Of Cell Proliferation Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Regulation Of Defense Response To Virus By Host Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination CAAX-box Protein Processing Negative Regulation Of Protein Targeting To Membrane Regulation Of Ruffle Assembly Positive Regulation Of MDA-5 Signaling Pathway Positive Regulation Of RIG-I Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Mesoderm Formation Epithelial To Mesenchymal Transition Aortic Valve Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Vitamin D Biosynthetic Process Cell Migration Positive Regulation Of Cell Migration Hair Follicle Morphogenesis Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Transcription, DNA-templated Roof Of Mouth Development Cartilage Morphogenesis Trophoblast Giant Cell Differentiation Negative Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Left/right Pattern Formation Notch Signaling Involved In Heart Development Heterochromatin Organization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Bicellular Tight Junction Assembly
Pathways		Ub-specific processing proteases	Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases
GWAS			Psoriasis ( 20953189)
Interacting Genes		5 interacting genes: BRD4 CDK4 CDK6 LGMN SNAI1	33 interacting genes: ACTN2 BRMS1 CTDSP1 CTDSP2 CTDSPL EP300 FBXL14 FBXO22 GSK3B HOXD4 KRT31 KRT40 KRTAP10-3 LATS2 LSP1 MFHAS1 MID2 MTUS2 NBN NOTCH1 NOTCH2NLA OTUB1 PALB2 PAX2 PPIL2 PTEN PTPN1 RCOR1 TGFB1 TNFAIP3 TRIM23 USP17L2 XRCC3
Entrez ID		377630	6615
HPRD ID		16844	05025
Ensembl ID		ENSG00000223443	ENSG00000124216
Uniprot IDs		Q6R6M4	O95863
PDB IDs			2Y48 3W5K 3ZMT 4QLI
Enriched GO Terms of Interacting Partners?
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