SNAI1 and LSP1

Number of citations of the paper that reports this interaction (PubMedID 25640309)
5

Data Source:
BioGRID (two hybrid)

		SNAI1	LSP1
Description		snail family transcriptional repressor 1	lymphocyte specific protein 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Pericentric Heterochromatin Cytoplasm Cytosol	Plasma Membrane Actin Cytoskeleton Membrane Extracellular Exosome
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Kinase Binding Metal Ion Binding E-box Binding	Actin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Mesoderm Formation Epithelial To Mesenchymal Transition Aortic Valve Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Vitamin D Biosynthetic Process Cell Migration Positive Regulation Of Cell Migration Hair Follicle Morphogenesis Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Transcription, DNA-templated Roof Of Mouth Development Cartilage Morphogenesis Trophoblast Giant Cell Differentiation Negative Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Left/right Pattern Formation Notch Signaling Involved In Heart Development Heterochromatin Organization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Bicellular Tight Junction Assembly	Cellular Defense Response Signal Transduction
Pathways		Regulation of PTEN gene transcription Regulation of PTEN gene transcription
Drugs
Diseases
GWAS		Psoriasis ( 20953189)	Bladder cancer ( 24163127) Breast cancer ( 29059683 17529967 23535729 27117709 20453838) Breast cancer (estrogen-receptor negative) ( 27117709) Celiac disease ( 23936387) Diastolic blood pressure ( 27841878 27618452 30487518) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Granulocyte percentage of myeloid white cells ( 27863252) Hypertension ( 30487518) Inflammatory bowel disease ( 28067908 23128233) Mammographic density (dense area) ( 25342443) Mean arterial pressure ( 29403010 30487518) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (antihypertensives) ( 31015401) Medication use (beta blocking agents) ( 31015401) Methadone dose in opioid dependence ( 28115739) Milk allergy ( 25710614) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252) Potassium levels ( 29403010) Pulse pressure ( 27841878 30578418) Pulse pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure ( 27841878 29403010 27618452 30487518 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Ulcerative colitis ( 28067908 21297633)
Interacting Genes		33 interacting genes: ACTN2 BRMS1 CTDSP1 CTDSP2 CTDSPL EP300 FBXL14 FBXO22 GSK3B HOXD4 KRT31 KRT40 KRTAP10-3 LATS2 LSP1 MFHAS1 MID2 MTUS2 NBN NOTCH1 NOTCH2NLA OTUB1 PALB2 PAX2 PPIL2 PTEN PTPN1 RCOR1 TGFB1 TNFAIP3 TRIM23 USP17L2 XRCC3	10 interacting genes: ACTG1 BMPR2 GREB1 IL24 KLK6 LYPD3 MAPKAPK2 SCGB2A2 SNAI1 THRSP
Entrez ID		6615	4046
HPRD ID		05025	01083
Ensembl ID		ENSG00000124216	ENSG00000130592
Uniprot IDs		O95863	A8K7L8 P33241
PDB IDs		2Y48 3W5K 3ZMT 4QLI	3BH8 4NO0 4NO2
Enriched GO Terms of Interacting Partners?
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