SNAI1 and OTUB1

Number of citations of the paper that reports this interaction (PubMedID 29559747)
9

Data Source:
BioGRID (enzymatic study)

		SNAI1	OTUB1
Description		snail family transcriptional repressor 1	OTU deubiquitinase, ubiquitin aldehyde binding 1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Pericentric Heterochromatin Cytoplasm Cytosol	Nucleus Nucleoplasm Cytosol Extracellular Exosome
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Protein Binding Kinase Binding Metal Ion Binding E-box Binding	Thiol-dependent Ubiquitin-specific Protease Activity Protein Binding NEDD8-specific Protease Activity Ubiquitin Protein Ligase Binding Ubiquitin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Mesoderm Formation Epithelial To Mesenchymal Transition Aortic Valve Morphogenesis Epithelial To Mesenchymal Transition Involved In Endocardial Cushion Formation Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Vitamin D Biosynthetic Process Cell Migration Positive Regulation Of Cell Migration Hair Follicle Morphogenesis Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Positive Regulation Of Transcription, DNA-templated Roof Of Mouth Development Cartilage Morphogenesis Trophoblast Giant Cell Differentiation Negative Regulation Of Cell Differentiation Involved In Embryonic Placenta Development Left/right Pattern Formation Notch Signaling Involved In Heart Development Heterochromatin Organization Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Regulation Of Bicellular Tight Junction Assembly	Adaptive Immune Response DNA Repair Cellular Response To DNA Damage Stimulus Protein Deubiquitination Protein K48-linked Deubiquitination Cellular Response To Interleukin-1 Negative Regulation Of Histone H2A K63-linked Ubiquitination Negative Regulation Of Double-strand Break Repair
Pathways		Regulation of PTEN gene transcription Regulation of PTEN gene transcription	Ub-specific processing proteases Ovarian tumor domain proteases
Drugs
Diseases
GWAS		Psoriasis ( 20953189)	Bipolar disorder ( 31043756)
Interacting Genes		33 interacting genes: ACTN2 BRMS1 CTDSP1 CTDSP2 CTDSPL EP300 FBXL14 FBXO22 GSK3B HOXD4 KRT31 KRT40 KRTAP10-3 LATS2 LSP1 MFHAS1 MID2 MTUS2 NBN NOTCH1 NOTCH2NLA OTUB1 PALB2 PAX2 PPIL2 PTEN PTPN1 RCOR1 TGFB1 TNFAIP3 TRIM23 USP17L2 XRCC3	51 interacting genes: ACVR1 ACVR1B ANXA1 ANXA7 AURKA BIRC2 BMPR1A BMPR1B CDKN1A CPEB2 CSNK2A1 ECT2 ESR1 FOXM1 H2AX IL1RL2 KDM1A MAPT NEDD8 PJA1 RFFL RHOA RNF126 RNF128 SLC7A11 SMAD2 SMAD3 SMAD4 SMAD9 SNAI1 TGFBR1 TP53 TRAF6 TRIM54 TRIM55 TRIM63 TSC22D1 TTR UBA6 UBC UBD UBE2D2 UBE2D4 UBE2N UBE2S UBE2V2 UBE2Z UBE4B USP15 USP21 USP28
Entrez ID		6615	55611
HPRD ID		05025	08493
Ensembl ID		ENSG00000124216	ENSG00000167770
Uniprot IDs		O95863	B3KUV5 Q96FW1
PDB IDs		2Y48 3W5K 3ZMT 4QLI	2ZFY 3VON 4DDG 4DDI 4DHZ 4I6L 4LDT
Enriched GO Terms of Interacting Partners?
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