IRF6 and TLX2

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		IRF6	TLX2
Description		interferon regulatory factor 6	T cell leukemia homeobox 2
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Cell Junction Extracellular Exosome	Nuclear Chromatin Cellular_component Cytoplasm
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific DNA Binding
	Biological Process	Immune System Process Cell Cycle Arrest Negative Regulation Of Cell Proliferation Keratinocyte Differentiation Keratinocyte Proliferation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cell Development Roof Of Mouth Development Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Mammary Gland Epithelial Cell Differentiation	Mesoderm Formation Positive Regulation Of Transcription By RNA Polymerase II Enteric Nervous System Development Negative Regulation Of Dendrite Morphogenesis
Pathways		Interferon gamma signaling Interferon alpha/beta signaling
Drugs
Diseases		Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate IRF6-related disorders, including: Popliteal pterygium syndrome (PPS); Van der Woude syndrome (VWS)
GWAS		Alopecia areata ( 25608926) Alzheimer's disease (APOE e4 interaction) ( 25778476) Cleft lip ( 20436469) Cleft lip with or without cleft palate ( 28054174) Crohn's disease ( 28067908) Drug-induced liver injury in interferon-beta-treated multiple sclerosis ( 30013178) Inflammatory bowel disease ( 28067908) Nonsyndromic cleft lip ( 31609978) Nonsyndromic cleft lip with cleft palate ( 28232668) Nonsyndromic cleft lip with or without cleft palate ( 25775280) Nonsyndromic cleft palate ( 31609978) Orofacial clefts ( 19270707 22863734 28054174) Systolic blood pressure ( 30224653)
Interacting Genes		5 interacting genes: CENPF IRF8 RFX3 TLX2 ZBTB3	9 interacting genes: GTF2A1L IRF6 IRF9 MCM4 MEIS1 POU2F1 TLE1 YWHAH ZNF502
Entrez ID		3664	3196
HPRD ID		06227	07254
Ensembl ID		ENSG00000117595	ENSG00000115297
Uniprot IDs		G0Z349 O14896	O43763
PDB IDs			3A03
Enriched GO Terms of Interacting Partners?
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