TLX2 and IRF6

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		TLX2	IRF6
Description		T cell leukemia homeobox 2	interferon regulatory factor 6
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Cellular_component Cytoplasm	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Cell Junction Extracellular Exosome
	Molecular Function	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Sequence-specific DNA Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding
	Biological Process	Mesoderm Formation Positive Regulation Of Transcription By RNA Polymerase II Enteric Nervous System Development Negative Regulation Of Dendrite Morphogenesis	Immune System Process Cell Cycle Arrest Negative Regulation Of Cell Proliferation Keratinocyte Differentiation Keratinocyte Proliferation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cell Development Roof Of Mouth Development Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway Mammary Gland Epithelial Cell Differentiation
Pathways			Interferon gamma signaling Interferon alpha/beta signaling
Drugs
Diseases			Isolated orofacial clefts, including: Cleft lip with or without cleft palate; Cleft palate IRF6-related disorders, including: Popliteal pterygium syndrome (PPS); Van der Woude syndrome (VWS)
GWAS			Alopecia areata ( 25608926) Alzheimer's disease (APOE e4 interaction) ( 25778476) Cleft lip ( 20436469) Cleft lip with or without cleft palate ( 28054174) Crohn's disease ( 28067908) Drug-induced liver injury in interferon-beta-treated multiple sclerosis ( 30013178) Inflammatory bowel disease ( 28067908) Nonsyndromic cleft lip ( 31609978) Nonsyndromic cleft lip with cleft palate ( 28232668) Nonsyndromic cleft lip with or without cleft palate ( 25775280) Nonsyndromic cleft palate ( 31609978) Orofacial clefts ( 19270707 22863734 28054174) Systolic blood pressure ( 30224653)
Interacting Genes		9 interacting genes: GTF2A1L IRF6 IRF9 MCM4 MEIS1 POU2F1 TLE1 YWHAH ZNF502	5 interacting genes: CENPF IRF8 RFX3 TLX2 ZBTB3
Entrez ID		3196	3664
HPRD ID		07254	06227
Ensembl ID		ENSG00000115297	ENSG00000117595
Uniprot IDs		O43763	G0Z349 O14896
PDB IDs		3A03
Enriched GO Terms of Interacting Partners?
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