IRF2 and IRF2BP2

Number of citations of the paper that reports this interaction (PubMedID 12799427)
40

Data Source:
HPRD (in vivo, two hybrid)

		IRF2	IRF2BP2
Description		interferon regulatory factor 2	interferon regulatory factor 2 binding protein 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytosol Focal Adhesion	Nucleus Nucleoplasm Cytoplasm
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding	Transcription Corepressor Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Regulation Of Transcription, DNA-templated Blood Coagulation Cell Proliferation Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Immature B Cell Differentiation Regulation Of Transcription By RNA Polymerase II Protein Ubiquitination
Pathways		Interferon gamma signaling Interferon alpha/beta signaling Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Acute kidney injury in critical illness ( 27576016) Adverse response to drug ( 30420678) Chronic lymphocytic leukemia ( 28165464) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Lewy body disease ( 25188341) Night sleep phenotypes ( 27126917) Nonsyndromic cleft lip ( 31609978)	Bipolar disorder ( 22688191) C-reactive protein levels or LDL-cholesterol levels (pleiotropy) ( 27286809) C-reactive protein levels or total cholesterol levels (pleiotropy) ( 27286809) Cholesterol, total ( 24097068 25961943 20686565) Heel bone mineral density ( 30598549) LDL cholesterol ( 24097068 25961943 20686565) LDL cholesterol levels ( 28334899) Life threatening arrhythmia ( 22247754) Total cholesterol levels ( 28334899) White blood cell count (eosinophil) ( 28158719)
Interacting Genes		22 interacting genes: APP ATG7 BRD7 CSNK2A1 EP300 FKBP7 FOXK1 HMGB1 HMGN1 IRF1 IRF2BP1 IRF2BP2 IRF8 KAT2A KAT2B MDM2 NFKB1 PPP3CB PRKACA RELA SPI1 STAT1	3 interacting genes: IRF2 MTNR1B NFATC2
Entrez ID		3660	359948
HPRD ID		00962	17160
Ensembl ID		ENSG00000168310	ENSG00000168264
Uniprot IDs		P14316	Q7Z5L9
PDB IDs
Enriched GO Terms of Interacting Partners?
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