IL1B and ADRB2

Number of citations of the paper that reports this interaction (PubMedID 11238007)
4

Data Source:
HPRD (in vitro)

		IL1B	ADRB2
Description		interleukin 1 beta	adrenoceptor beta 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Cytosol Secretory Granule	Nucleus Lysosome Endosome Early Endosome Plasma Membrane Integral Component Of Plasma Membrane Endosome Membrane Membrane Apical Plasma Membrane Clathrin-coated Vesicle Membrane Receptor Complex
	Molecular Function	Cytokine Activity Interleukin-1 Receptor Binding Integrin Binding Protein Binding Protein Domain Specific Binding	Amyloid-beta Binding Adrenergic Receptor Activity Beta2-adrenergic Receptor Activity Protein Binding Adenylate Cyclase Binding Potassium Channel Regulator Activity Identical Protein Binding Protein Homodimerization Activity Protein-containing Complex Binding Epinephrine Binding Norepinephrine Binding
	Biological Process	MAPK Cascade Activation Of MAPK Activity Fever Generation Positive Regulation Of Protein Phosphorylation Inflammatory Response To Antigenic Stimulus Positive Regulation Of T Cell Mediated Immunity Apoptotic Process Inflammatory Response Signal Transduction Cell-cell Signaling Embryo Implantation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Response To Carbohydrate Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Glucose Transmembrane Transport Smooth Muscle Adaptation Cytokine-mediated Signaling Pathway Hyaluronan Biosynthetic Process Positive Regulation Of Cell Migration Neutrophil Chemotaxis Sequestering Of Triglyceride Positive Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Fever Generation Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Prostaglandin Secretion Response To Lipopolysaccharide Interleukin-1 Beta Production Interleukin-6 Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Immature T Cell Proliferation In Thymus Positive Regulation Of Histone Phosphorylation Response To ATP Positive Regulation Of Heterotypic Cell-cell Adhesion Positive Regulation Of Histone Acetylation Ectopic Germ Cell Programmed Cell Death Positive Regulation Of Myosin Light Chain Kinase Activity Cellular Response To Drug Positive Regulation Of T Cell Proliferation Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of MAP Kinase Activity Protein Kinase B Signaling Positive Regulation Of Chemokine Biosynthetic Process Positive Regulation Of Interleukin-2 Biosynthetic Process Positive Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Angiogenesis Negative Regulation Of Lipid Metabolic Process Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Complement Activation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Negative Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Protein Export From Nucleus Astrocyte Activation Regulation Of Defense Response To Virus By Host Positive Regulation Of Inflammatory Response Positive Regulation Of Phagocytosis Regulation Of Neurogenesis Negative Regulation Of Neurogenesis Regulation Of Insulin Secretion Negative Regulation Of Synaptic Transmission Negative Regulation Of Lipid Catabolic Process Positive Regulation Of Lipid Catabolic Process Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Cell Division Positive Regulation Of Glial Cell Proliferation Positive Regulation Of Cell Adhesion Molecule Production Positive Regulation Of Calcidiol 1-monooxygenase Activity Negative Regulation Of Adiponectin Secretion Regulation Of ERK1 And ERK2 Cascade Monocyte Aggregation Interleukin-1-mediated Signaling Pathway Response To Interleukin-1 Cellular Response To Lipopolysaccharide Cellular Response To Mechanical Stimulus Cellular Response To Organic Substance Cellular Response To Organic Cyclic Compound Positive Regulation Of Monocyte Chemotactic Protein-1 Production Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Positive Regulation Of Neuroinflammatory Response Positive Regulation Of P38MAPK Cascade Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of RNA Biosynthetic Process Regulation Of Establishment Of Endothelial Barrier Negative Regulation Of Gap Junction Assembly Positive Regulation Of T-helper 1 Cell Cytokine Production Positive Regulation Of Interleukin-6 Secretion Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand	Diet Induced Thermogenesis Norepinephrine-epinephrine-mediated Vasodilation Involved In Regulation Of Systemic Arterial Blood Pressure Regulation Of Sodium Ion Transport Desensitization Of G Protein-coupled Receptor Signaling Pathway By Arrestin Receptor-mediated Endocytosis Cell Surface Receptor Signaling Pathway Activation Of Transmembrane Receptor Protein Tyrosine Kinase Activity G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Activation Of Adenylate Cyclase Activity Cell-cell Signaling Behavior Endosome To Lysosome Transport Response To Cold Positive Regulation Of Protein Kinase A Signaling Protein Deubiquitination Positive Regulation Of Bone Mineralization Positive Regulation Of Protein Ubiquitination Heat Generation Negative Regulation Of Multicellular Organism Growth Positive Regulation Of MAPK Cascade Bone Resorption Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Smooth Muscle Contraction Brown Fat Cell Differentiation Membrane Organization Positive Regulation Of Mini Excitatory Postsynaptic Potential Adrenergic Receptor Signaling Pathway Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Positive Regulation Of Protein Serine/threonine Kinase Activity Positive Regulation Of Cold-induced Thermogenesis Positive Regulation Of Autophagosome Maturation Positive Regulation Of Lipophagy Cellular Response To Amyloid-beta Response To Psychosocial Stress Positive Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of AMPA Receptor Activity
Pathways		Interleukin-1 processing CLEC7A/inflammasome pathway Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Interleukin-1 signaling Purinergic signaling in leishmaniasis infection	Adrenoceptors G alpha (s) signalling events Ub-specific processing proteases Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis ADORA2B mediated anti-inflammatory cytokines production
Drugs		Minocycline VP025 Gallium nitrate Talmapimod Etiprednol dicloacetate VX-702 VX-765 Andrographolide Canakinumab Rilonacept Binimetinib Gevokizumab Dilmapimod	Spermine Amphetamine Betaxolol Bethanidine Isoetarine Cabergoline Metoprolol Amitriptyline Olanzapine Atenolol Norepinephrine Mirtazapine Timolol Phenylpropanolamine Dipivefrin Sotalol Carteolol Nortriptyline Propranolol Labetalol Bisoprolol Epinephrine Trimipramine Orciprenaline Dobutamine Pseudoephedrine Alprenolol Ritodrine Terbutaline Bitolterol Phenoxybenzamine Salmeterol Pindolol Formoterol Salbutamol Isoprenaline Arbutamine Carvedilol Desipramine Propafenone Acebutolol Nadolol Levobunolol Metipranolol Arformoterol Fenoterol Pirbuterol Bevantolol Penbutolol Ephedra Mephentermine Procaterol Clenbuterol Bambuterol Oxprenolol Putrescine Spermidine Celiprolol Nebivolol Indacaterol NCX 950 Asenapine Droxidopa Bufuralol (2S)-1-(9H-Carbazol-4-yloxy)-3-(isopropylamino)propan-2-ol Bopindolol Bupranolol Befunolol Olodaterol Vilanterol Tulobuterol Levosalbutamol
Diseases			Asthma
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Birth weight ( 31043758) Dysmenorrheic pain severity ( 29855537) Gestational age at birth (child effect) ( 31477735) Post-term birth ( 31477735)	Chronic obstructive pulmonary disease ( 30804561) FEV1 ( 30804560) Lung function (FEV1/FVC) ( 30804560) Lymphocyte percentage of white cells ( 27863252) Peak expiratory flow ( 30804560) Systolic blood pressure ( 29615537)
Interacting Genes		15 interacting genes: A2M ADRB2 APP CASP1 CASP4 CMA1 EGR1 FYN IL1R1 IL1R2 IL1RAP LYN MMP2 PRTN3 SP1	92 interacting genes: ADGRG1 ADRB3 AKAP12 AKAP5 ALDOA ARF4 ARHGAP5 ARHGDIA ARR3 ARRB1 ARRB2 ARRDC3 CCKBR CD4 CD68 CD81 CD9 CEACAM1 CNN1 CSK EGLN3 EIF2B1 GMPR2 GNA11 GNA14 GNA15 GNAI2 GNAS GNAT2 GNB1 GNG2 GNL3L GPR37 GPRASP1 GPRC5B GRB2 GRIA3 GRK1 GRK2 GRK3 GRK4 GRK5 GRK6 HDAC6 HTR4 IL1B IL6R INSR KCNE1 KCNJ6 KCNJ9 KCTD13 MAPK8IP2 MCAM MDM2 NEDD4 NOS1 OPRD1 PLA2G2D PRKCD PTGER1 RAB27A RAB3A RACK1 RAN RAP2C REL RGS10 RGS11 RGS17 RGS2 RGS20 RGS5 RGS8 RGS9 RHOD RNF41 SLC52A2 SLC9A3R1 SLC9A3R2 SNCG SRC STAT3 STAT4 TSG101 TSHR UCHL1 VAPA VDAC1 VDAC2 VEGFB WNK1
Entrez ID		3553	154
HPRD ID		00985	00187
Ensembl ID		ENSG00000125538	ENSG00000169252
Uniprot IDs		P01584	P07550
PDB IDs		1HIB 1I1B 1IOB 1ITB 1L2H 1S0L 1T4Q 1TOO 1TP0 1TWE 1TWM 21BI 2I1B 2KH2 2NVH 31BI 3LTQ 3O4O 3POK 41BI 4DEP 4G6J 4G6M 4GAF 4GAI 4I1B 5BVP 5I1B 5MVZ 6I1B 7I1B 9ILB	1GQ4 2R4R 2R4S 2RH1 3D4S 3KJ6 3NY8 3NY9 3NYA 3P0G 3PDS 3SN6 4GBR 4LDE 4LDL 4LDO 4QKX 5D5A 5D5B 5D6L 5JQH 5X7D 6E67 6MXT 6N48 6NI3 6PRZ 6PS0 6PS1 6PS2 6PS3 6PS4 6PS5 6PS6
Enriched GO Terms of Interacting Partners?
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