IGSF1 and ACVR2B

Number of citations of the paper that reports this interaction (PubMedID 11266516)
11

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		IGSF1	ACVR2B
Description		immunoglobulin superfamily member 1	activin A receptor type 2B
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Membrane Integral Component Of Membrane	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Protein-containing Complex Receptor Complex Activin Receptor Complex
	Molecular Function	Protein Binding Coreceptor Activity Inhibin Binding Activin Receptor Antagonist Activity	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Activin Receptor Activity, Type II Activin-activated Receptor Activity Growth Factor Binding Metal Ion Binding Activin Binding
	Biological Process	Regulation Of Transcription, DNA-templated Negative Regulation Of Activin Receptor Signaling Pathway	Negative Regulation Of Transcription By RNA Polymerase II Gastrulation With Mouth Forming Second Kidney Development Lymphangiogenesis Blood Vessel Remodeling Regulation Of Transcription, DNA-templated Protein Phosphorylation Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Determination Of Left/right Symmetry Mesoderm Development Heart Development Response To Glucose Post-embryonic Development Anterior/posterior Pattern Specification Insulin Secretion Lung Development Positive Regulation Of Bone Mineralization BMP Signaling Pathway Pancreas Development Activation Of Protein Kinase Activity Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Organ Growth Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Osteoblast Differentiation Embryonic Foregut Morphogenesis Skeletal System Morphogenesis Roof Of Mouth Development Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Retina Vasculature Development In Camera-type Eye Cellular Response To Growth Factor Stimulus Negative Regulation Of Cold-induced Thermogenesis
Pathways			Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP
Drugs
Diseases			Heterotaxy; Situs ambiguus
GWAS		Age at voice drop ( 27182965) Menarche (age at onset) ( 27182965)	Bitter beverage consumption ( 31046077) Estimated glomerular filtration rate ( 31152163 31015462) P wave duration ( 24850809)
Interacting Genes		8 interacting genes: ACVR1 ACVR1B ACVR2A ACVR2B HECTD1 IGF1 INHBB RANBP10	21 interacting genes: ACVR1B BMP10 BMP2 BMP7 ERBIN FBXO7 GDF11 GDF2 GDF5 IGSF1 INHBA INHBB INHBC MSTN NODAL SNX1 SNX2 SNX6 SYNJ2BP TDGF1 TGFBRAP1
Entrez ID		3547	93
HPRD ID		02138	04106
Ensembl ID		ENSG00000147255	ENSG00000114739
Uniprot IDs		Q8N6C5	Q13705
PDB IDs			2H62 2QLU 4FAO 5NGV 5NHR
Enriched GO Terms of Interacting Partners?
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