ACVR2B and GDF11

Number of citations of the paper that reports this interaction (PubMedID 16845371)
46

Data Source:
HPRD (in vivo, in vitro)

		ACVR2B	GDF11
Description		activin A receptor type 2B	growth differentiation factor 11
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Protein-containing Complex Receptor Complex Activin Receptor Complex	Extracellular Space Nucleoplasm Protein-containing Complex Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Activin Receptor Activity, Type II Activin-activated Receptor Activity Growth Factor Binding Metal Ion Binding Activin Binding	Cytokine Activity Protein Binding Growth Factor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Gastrulation With Mouth Forming Second Kidney Development Lymphangiogenesis Blood Vessel Remodeling Regulation Of Transcription, DNA-templated Protein Phosphorylation Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Determination Of Left/right Symmetry Mesoderm Development Heart Development Response To Glucose Post-embryonic Development Anterior/posterior Pattern Specification Insulin Secretion Lung Development Positive Regulation Of Bone Mineralization BMP Signaling Pathway Pancreas Development Activation Of Protein Kinase Activity Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Organ Growth Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Osteoblast Differentiation Embryonic Foregut Morphogenesis Skeletal System Morphogenesis Roof Of Mouth Development Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Retina Vasculature Development In Camera-type Eye Cellular Response To Growth Factor Stimulus Negative Regulation Of Cold-induced Thermogenesis	Skeletal System Development Metanephros Development Ureteric Bud Development Nervous System Development Mesoderm Development Negative Regulation Of Cell Proliferation Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Spinal Cord Anterior/posterior Patterning Pancreas Development Negative Regulation Of Neuron Differentiation Cell Maturation Camera-type Eye Morphogenesis Roof Of Mouth Development SMAD Protein Signal Transduction
Pathways		Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP
Drugs
Diseases		Heterotaxy; Situs ambiguus
GWAS		Bitter beverage consumption ( 31046077) Estimated glomerular filtration rate ( 31152163 31015462) P wave duration ( 24850809)
Interacting Genes		21 interacting genes: ACVR1B BMP10 BMP2 BMP7 ERBIN FBXO7 GDF11 GDF2 GDF5 IGSF1 INHBA INHBB INHBC MSTN NODAL SNX1 SNX2 SNX6 SYNJ2BP TDGF1 TGFBRAP1	2 interacting genes: ACVR2B RNF41
Entrez ID		93	10220
HPRD ID		04106	04895
Ensembl ID		ENSG00000114739	ENSG00000135414
Uniprot IDs		Q13705	A0A024RB20 O95390
PDB IDs		2H62 2QLU 4FAO 5NGV 5NHR	5E4G 5JHW 5UHM 6MAC
Enriched GO Terms of Interacting Partners?
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