LCE2D and SPRY1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		LCE2D	SPRY1
Description		late cornified envelope 2D	sprouty RTK signaling antagonist 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Cell Nucleoplasm Golgi Apparatus Cytosol Plasma Membrane
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Keratinization	Establishment Of Mitotic Spindle Orientation Metanephros Development Ureteric Bud Development Organ Induction Negative Regulation Of Cell Proliferation Negative Regulation Of GTPase Activity Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of MAP Kinase Activity Negative Regulation Of Ras Protein Signal Transduction Animal Organ Development Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Bud Elongation Involved In Lung Branching Epithelial To Mesenchymal Transition Involved In Cardiac Fibroblast Development Negative Regulation Of ERK1 And ERK2 Cascade
Pathways		Formation of the cornified envelope	EGFR downregulation
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011)	Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Irritable bowel syndrome ( 24797007) Itch intensity from mosquito bite adjusted by bite size ( 28199695) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Metabolite levels ( 23823483) Pelvic organ prolapse ( 26545240) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858)
Interacting Genes		14 interacting genes: ADAMTSL4 EFEMP2 GLRX3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP4-12 NOTCH2NLA OTX1 PLSCR1 RGS20 SPRY1 SPRY2 SUMO1P1	27 interacting genes: ATXN7 CACNA1A CREB5 GEMIN4 GRB2 HEXIM2 HOXA1 HRG KPNA2 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-2 LCE1B LCE2D MDFI MEOX2 NOTCH2NLA OTX1 R3HDM2 SOCS4 SPRY2 STAT3 YY1
Entrez ID		353141	10252
HPRD ID		17261	06782
Ensembl ID		ENSG00000187223	ENSG00000164056
Uniprot IDs		Q5TA82	O43609
PDB IDs
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?