SPRY1 and HEXIM2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		SPRY1	HEXIM2
Description		sprouty RTK signaling antagonist 1	HEXIM P-TEFb complex subunit 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cell Nucleoplasm Golgi Apparatus Cytosol Plasma Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Speck
	Molecular Function	Protein Binding	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding SnRNA Binding Identical Protein Binding 7SK SnRNA Binding
	Biological Process	Establishment Of Mitotic Spindle Orientation Metanephros Development Ureteric Bud Development Organ Induction Negative Regulation Of Cell Proliferation Negative Regulation Of GTPase Activity Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of MAP Kinase Activity Negative Regulation Of Ras Protein Signal Transduction Animal Organ Development Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Bud Elongation Involved In Lung Branching Epithelial To Mesenchymal Transition Involved In Cardiac Fibroblast Development Negative Regulation Of ERK1 And ERK2 Cascade	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription, DNA-templated
Pathways		EGFR downregulation
Drugs
Diseases
GWAS		Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Irritable bowel syndrome ( 24797007) Itch intensity from mosquito bite adjusted by bite size ( 28199695) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Metabolite levels ( 23823483) Pelvic organ prolapse ( 26545240) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858)	Asthma ( 31619474) Craniofacial microsomia ( 26853712) Male-pattern baldness ( 28196072) Systolic blood pressure ( 19430483)
Interacting Genes		27 interacting genes: ATXN7 CACNA1A CREB5 GEMIN4 GRB2 HEXIM2 HOXA1 HRG KPNA2 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-2 LCE1B LCE2D MDFI MEOX2 NOTCH2NLA OTX1 R3HDM2 SOCS4 SPRY2 STAT3 YY1	15 interacting genes: CCNT1 CDK9 GATA1 IHO1 MEOX2 PIM1 PIN1 PRDM14 RNPS1 SPRY1 SPRY2 TADA3 TERF1 TERF2 ZNF250
Entrez ID		10252	124790
HPRD ID		06782	08129
Ensembl ID		ENSG00000164056	ENSG00000168517
Uniprot IDs		O43609	Q96MH2
PDB IDs
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?