SPRY1 and SOCS4

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		SPRY1	SOCS4
Description		sprouty RTK signaling antagonist 1	suppressor of cytokine signaling 4
Image		No pdb structure
GO Annotations	Cellular Component	Cell Nucleoplasm Golgi Apparatus Cytosol Plasma Membrane	Phosphatidylinositol 3-kinase Complex
	Molecular Function	Protein Binding	Protein Binding 1-phosphatidylinositol-3-kinase Regulator Activity
	Biological Process	Establishment Of Mitotic Spindle Orientation Metanephros Development Ureteric Bud Development Organ Induction Negative Regulation Of Cell Proliferation Negative Regulation Of GTPase Activity Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of MAP Kinase Activity Negative Regulation Of Ras Protein Signal Transduction Animal Organ Development Negative Regulation Of Neurotrophin TRK Receptor Signaling Pathway Bud Elongation Involved In Lung Branching Epithelial To Mesenchymal Transition Involved In Cardiac Fibroblast Development Negative Regulation Of ERK1 And ERK2 Cascade	Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Intracellular Signal Transduction Regulation Of Growth Regulation Of Phosphatidylinositol 3-kinase Activity Phosphatidylinositol Phosphorylation
Pathways		EGFR downregulation	RUNX1 regulates transcription of genes involved in differentiation of keratinocytes
Drugs
Diseases
GWAS		Diastolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Irritable bowel syndrome ( 24797007) Itch intensity from mosquito bite adjusted by bite size ( 28199695) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) Metabolite levels ( 23823483) Pelvic organ prolapse ( 26545240) Systolic blood pressure x smoking status (current vs non-current) interaction (1df test) ( 29455858)
Interacting Genes		27 interacting genes: ATXN7 CACNA1A CREB5 GEMIN4 GRB2 HEXIM2 HOXA1 HRG KPNA2 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-2 LCE1B LCE2D MDFI MEOX2 NOTCH2NLA OTX1 R3HDM2 SOCS4 SPRY2 STAT3 YY1	10 interacting genes: CNMD EGFR LDHAL6B MDFIC MPP5 NR4A1 PLPP6 SPRY1 TNK2 VWF
Entrez ID		10252	122809
HPRD ID		06782	18084
Ensembl ID		ENSG00000164056	ENSG00000180008
Uniprot IDs		O43609	Q5H9R6 Q8WXH5
PDB IDs			2IZV
Enriched GO Terms of Interacting Partners?
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Tagcloud (Difference) ?
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