MMAB and MTRR

Number of citations of the paper that reports this interaction (PubMedID 15347655)
25

Data Source:
HPRD (in vitro)

		MMAB	MTRR
Description		metabolism of cobalamin associated B	5-methyltetrahydrofolate-homocysteine methyltransferase reductase
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GO Annotations	Cellular Component	Mitochondrial Matrix	Cytosol
	Molecular Function	Protein Binding ATP Binding Cob(I)yrinic Acid A,c-diamide Adenosyltransferase Activity Cobalamin Binding	NADPH-hemoprotein Reductase Activity Protein Binding FMN Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Oxidoreductase Activity, Oxidizing Metal Ions, NAD Or NADP As Acceptor [methionine Synthase] Reductase Activity Aquacobalamin Reductase (NADPH) Activity Flavin Adenine Dinucleotide Binding NADP Binding NADPH Binding FAD Binding
	Biological Process	Cobalamin Metabolic Process Cobalamin Biosynthetic Process	Sulfur Amino Acid Metabolic Process DNA Methylation Methionine Metabolic Process Methionine Biosynthetic Process Cobalamin Metabolic Process Methylation S-adenosylmethionine Cycle Homocysteine Catabolic Process Folic Acid Metabolic Process Homocysteine Metabolic Process Oxidation-reduction Process Negative Regulation Of Cystathionine Beta-synthase Activity
Pathways		Cobalamin (Cbl, vitamin B12) transport and metabolism Defective MMAB causes methylmalonic aciduria type cblB	Methylation Sulfur amino acid metabolism Cobalamin (Cbl, vitamin B12) transport and metabolism Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective MTR causes methylmalonic aciduria and homocystinuria type cblG
Drugs		Hydroxocobalamin	Cyanocobalamin L-Methionine Hydroxocobalamin
Diseases		Methylmalonic aciduria (MMA)	Spina bifida Homocystinuria
GWAS		Age-related nuclear cataracts ( 24951543) HDL cholesterol ( 18193043 20864672 19060906 25961943 20686565) HDL cholesterol levels x long total sleep time interaction (2df test) ( 31719535) HDL cholesterol levels x short total sleep time interaction (2df test) ( 31719535) Polymyositis ( 26362759)	Capecitabine sensitivity ( 22864933) Hyperinsulinemia in lower physical activity ( 30327367) Metabolite levels ( 23823483) Verbal declarative memory ( 25648963)
Interacting Genes		2 interacting genes: CBY2 MTRR	3 interacting genes: GFER GMCL1 MMAB
Entrez ID		326625	4552
HPRD ID		07398	03979
Ensembl ID		ENSG00000139428	ENSG00000124275
Uniprot IDs		Q96EY8	Q9UBK8
PDB IDs		2IDX 6D5K 6D5X	2QTL 2QTZ
Enriched GO Terms of Interacting Partners?
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