MTRR

Description		5-methyltetrahydrofolate-homocysteine methyltransferase reductase
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GO Annotations	Cellular Component	Cytosol
	Molecular Function	NADPH-hemoprotein Reductase Activity Protein Binding FMN Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Oxidoreductase Activity, Oxidizing Metal Ions, NAD Or NADP As Acceptor [methionine Synthase] Reductase Activity Aquacobalamin Reductase (NADPH) Activity Flavin Adenine Dinucleotide Binding NADP Binding NADPH Binding FAD Binding
	Biological Process	Sulfur Amino Acid Metabolic Process DNA Methylation Methionine Metabolic Process Methionine Biosynthetic Process Cobalamin Metabolic Process Methylation S-adenosylmethionine Cycle Homocysteine Catabolic Process Folic Acid Metabolic Process Homocysteine Metabolic Process Oxidation-reduction Process Negative Regulation Of Cystathionine Beta-synthase Activity
Pathways		Methylation Sulfur amino acid metabolism Cobalamin (Cbl, vitamin B12) transport and metabolism Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective MTR causes methylmalonic aciduria and homocystinuria type cblG
Drugs		Cyanocobalamin L-Methionine Hydroxocobalamin
Diseases		Spina bifida Homocystinuria
GWAS		Capecitabine sensitivity ( 22864933) Hyperinsulinemia in lower physical activity ( 30327367) Metabolite levels ( 23823483) Verbal declarative memory ( 25648963)
Interacting Genes		3 interacting genes: GFER GMCL1 MMAB
Entrez ID		4552
HPRD ID		03979
Ensembl ID		ENSG00000124275
Uniprot IDs		Q9UBK8
PDB IDs		2QTL 2QTZ
Enriched GO Terms of Interacting Partners?
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