MTRR and GFER

		MTRR	GFER
Description		5-methyltetrahydrofolate-homocysteine methyltransferase reductase	growth factor, augmenter of liver regeneration
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GO Annotations	Cellular Component	Cytosol	Extracellular Region Mitochondrion Mitochondrial Intermembrane Space Cytosol
	Molecular Function	NADPH-hemoprotein Reductase Activity Protein Binding FMN Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On Paired Donors, With Incorporation Or Reduction Of Molecular Oxygen, NAD(P)H As One Donor, And Incorporation Of One Atom Of Oxygen Oxidoreductase Activity, Oxidizing Metal Ions, NAD Or NADP As Acceptor [methionine Synthase] Reductase Activity Aquacobalamin Reductase (NADPH) Activity Flavin Adenine Dinucleotide Binding NADP Binding NADPH Binding FAD Binding	Protein Binding Growth Factor Activity Protein Disulfide Oxidoreductase Activity Flavin-linked Sulfhydryl Oxidase Activity Flavin Adenine Dinucleotide Binding
	Biological Process	Sulfur Amino Acid Metabolic Process DNA Methylation Methionine Metabolic Process Methionine Biosynthetic Process Cobalamin Metabolic Process Methylation S-adenosylmethionine Cycle Homocysteine Catabolic Process Folic Acid Metabolic Process Homocysteine Metabolic Process Oxidation-reduction Process Negative Regulation Of Cystathionine Beta-synthase Activity	Liver Development Signal Transduction Oxidation-reduction Process
Pathways		Methylation Sulfur amino acid metabolism Cobalamin (Cbl, vitamin B12) transport and metabolism Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE Defective MTR causes methylmalonic aciduria and homocystinuria type cblG	Mitochondrial protein import
Drugs		Cyanocobalamin L-Methionine Hydroxocobalamin	Flavin adenine dinucleotide
Diseases		Spina bifida Homocystinuria
GWAS		Capecitabine sensitivity ( 22864933) Hyperinsulinemia in lower physical activity ( 30327367) Metabolite levels ( 23823483) Verbal declarative memory ( 25648963)
Interacting Genes		3 interacting genes: GFER GMCL1 MMAB	10 interacting genes: ASCC2 BNIPL COPS2 COPS5 METTL9 MTRR NPIPA1 PLEKHF2 SMAD2 TXN
Entrez ID		4552	2671
HPRD ID		03979	02954
Ensembl ID		ENSG00000124275	ENSG00000127554
Uniprot IDs		Q9UBK8	P55789
PDB IDs		2QTL 2QTZ	3MBG 3O55 3TK0 3U2L 3U2M 3U5S 4LDK
Enriched GO Terms of Interacting Partners?
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