HOXA3 and ALX4

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		HOXA3	ALX4
Description		homeobox A3	ALX homeobox 4
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm	Nuclear Chromatin Nucleus Nucleoplasm Transcription Factor Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding HMG Box Domain Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding HMG Box Domain Binding
	Biological Process	Angiogenesis Blood Vessel Remodeling Positive Regulation Of Cell Proliferation Anterior/posterior Pattern Specification Specification Of Animal Organ Position Gene Expression Glossopharyngeal Nerve Morphogenesis Thyroid Gland Development Positive Regulation Of Transcription By RNA Polymerase II Thymus Development Animal Organ Formation Embryonic Skeletal System Morphogenesis Cartilage Development Parathyroid Gland Development Positive Regulation Of Receptor Binding	Skeletal System Development Hair Follicle Development Muscle Organ Development Post-embryonic Development Anterior/posterior Pattern Specification Embryonic Forelimb Morphogenesis Embryonic Hindlimb Morphogenesis Embryonic Digit Morphogenesis Regulation Of Apoptotic Process Positive Regulation Of Transcription By RNA Polymerase II Digestive Tract Development Embryonic Skeletal System Morphogenesis Roof Of Mouth Development
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases			Frontonasal dysplasia Enlarged parietal foramina/cranium bifidum
GWAS		Chronic venous disease ( 28374850) Diastolic blood pressure ( 27618448) Hypertension ( 27618448 30487518) Mean arterial pressure ( 27618448) Monocyte count ( 27863252) Pulse pressure ( 30487518) Systolic blood pressure ( 28135244 27618448 30487518)	Blood pressure measurement (high sodium intervention) ( 24165912) Cadmium levels ( 26025379) Excessive hairiness ( 29895819) Gout ( 22179738) Male-pattern baldness ( 29146897 27182965) Monobrow ( 27182965) Response to antidepressants in depression ( 29998114) Thrombin-activatable fibrinolysis inhibitor activation peptide ( 29378355)
Interacting Genes		9 interacting genes: ALX4 ARPC3 POT1 PWP1 SEC23B SOX10 TERF1 TINF2 ZDHHC17	12 interacting genes: ALX1 CEBPE EMX1 FOXA3 GATA4 HOXA3 HOXB13 HOXB6 HOXD3 LEF1 SOX10 SOX2
Entrez ID		3200	60529
HPRD ID		00842	05661
Ensembl ID		ENSG00000105997	ENSG00000052850
Uniprot IDs		A0A024RA33 A4D182 B3KPN8 O43365	Q9H161
PDB IDs			2M0C
Enriched GO Terms of Interacting Partners?
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