HNF4G and NSD1

Number of citations of the paper that reports this interaction (PubMedID 23975195)
7

Data Source:
BioGRID (two hybrid)

		HNF4G	NSD1
Description		hepatocyte nuclear factor 4 gamma	nuclear receptor binding SET domain protein 1
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Centrosome Cytosol	Chromatin Nucleus Nucleoplasm
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Zinc Ion Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding Chromatin Binding Transcription Coregulator Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Estrogen Receptor Binding Histone Methyltransferase Activity (H4-K20 Specific) Retinoic Acid Receptor Binding Retinoid X Receptor Binding Thyroid Hormone Receptor Binding Histone Methyltransferase Activity (H3-K36 Specific) Androgen Receptor Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Cell Differentiation Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Development	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Histone H3-K36 Methylation Regulation Of Transcription, DNA-templated Histone H3-K36 Methylation Histone Methylation Regulation Of Peptidyl-serine Phosphorylation Histone H4-K20 Methylation Positive Regulation Of Transcription, DNA-templated Regulation Of RNA Polymerase II Regulatory Region Sequence-specific DNA Binding
Pathways		Regulation of gene expression in beta cells Nuclear Receptor transcription pathway	PKMTs methylate histone lysines
Drugs		Palmitic Acid
Diseases			Beckwith-Wiedemann syndrome Sotos syndrome and Weaver syndrome
GWAS		Attention function ( 29907492) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 26426971 28892062 25673413 20935630 28448500) Body mass index (age <50) ( 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body mass index in physically inactive individuals ( 28448500) Body mass index x sex x age interaction (4df test) ( 26426971) Breast cancer ( 29059683 23535729) Chronotype ( 30696823) Estimated glomerular filtration rate ( 31152163) Morning person ( 30696823) Number of sexual partners ( 30643258) Obesity ( 23563607) Pancreatic cancer ( 29422604) Pulse pressure ( 27841878) Serum uric acid levels ( 30993211 29403010) Systolic blood pressure ( 27841878) Urate levels ( 31578528 23263486) Waist circumference adjusted for body mass index ( 28552196)	Activated partial thromboplastin time ( 22703881) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Circulating fibroblast growth factor 23 levels ( 30217807) Height ( 25282103 31562340) Narrowest width of the femoral neck ( 30888730) Nonsyndromic cleft lip ( 31609978) Urate levels ( 31578528) Urate levels in lean individuals ( 25811787) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		15 interacting genes: COPS5 DNMT3L ELOC GAPDH HAX1 HLF NCOA1 NR0B2 NSD1 PNRC1 PNRC2 PRDX6 PSMC5 RANBP9 TNNI2	32 interacting genes: AR ATRX ESR1 ESRRA H1-2 H1-3 H1-5 H3-4 H3C1 H4-16 H4C1 HNF4G NR2E1 NR2F1 NR2F2 NR2F6 NR5A2 NR6A1 NTRK3 POLR2A PPARG RARA RORA RORB RTN4 RXRA SNORD3A THRA THRB TNFRSF21 VDR ZNF496
Entrez ID		3174	64324
HPRD ID		06909	09455
Ensembl ID		ENSG00000164749	ENSG00000165671
Uniprot IDs		F1D8Q4 Q14541	Q96L73 Q96MN8
PDB IDs		1LV2	3OOI
Enriched GO Terms of Interacting Partners?
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