HMGN1 and IRF2

Number of citations of the paper that reports this interaction (PubMedID 11025449)
10

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		HMGN1	IRF2
Description		high mobility group nucleosome binding domain 1	interferon regulatory factor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm	Nuclear Chromatin Nucleus Nucleoplasm Cytosol Focal Adhesion
	Molecular Function	DNA Binding Nucleosomal DNA Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding
	Biological Process	Pyrimidine Dimer Repair By Nucleotide-excision Repair Transcription-coupled Nucleotide-excision Repair Chromatin Organization Regulation Of Transcription By RNA Polymerase II Response To UV-B Response To UV-C Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Development, Heterochronic Post-embryonic Camera-type Eye Morphogenesis Regulation Of Epithelial Cell Proliferation Positive Regulation Of NAD+ ADP-ribosyltransferase Activity	Negative Regulation Of Transcription By RNA Polymerase II Immune System Process Regulation Of Transcription, DNA-templated Blood Coagulation Cell Proliferation Positive Regulation Of Transcription By RNA Polymerase II Defense Response To Virus Interferon-gamma-mediated Signaling Pathway Type I Interferon Signaling Pathway
Pathways		Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER	Interferon gamma signaling Interferon alpha/beta signaling Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Smoking status (ever vs never smokers) ( 30643258)	Acute kidney injury in critical illness ( 27576016) Adverse response to drug ( 30420678) Chronic lymphocytic leukemia ( 28165464) Hippocampal volume in Alzheimer's disease dementia ( 29274321) Lewy body disease ( 25188341) Night sleep phenotypes ( 27126917) Nonsyndromic cleft lip ( 31609978)
Interacting Genes		20 interacting genes: CHEK2 EP300 HMGN2 HPF1 IRF2 LIG4 MDM2 NFE2 PARP1 PPP1CC PRKACA PRKACG PRKCA RPS6KA3 RPS6KA4 RPS6KA5 SLC38A3 SPP1 TERF2 YWHAZ	22 interacting genes: APP ATG7 BRD7 CSNK2A1 EP300 FKBP7 FOXK1 HMGB1 HMGN1 IRF1 IRF2BP1 IRF2BP2 IRF8 KAT2A KAT2B MDM2 NFKB1 PPP3CB PRKACA RELA SPI1 STAT1
Entrez ID		3150	3660
HPRD ID		01231	00962
Ensembl ID		ENSG00000205581	ENSG00000168310
Uniprot IDs		P05114 Q6NSG7	P14316
PDB IDs
Enriched GO Terms of Interacting Partners?
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