HMGN1 and SPP1

Number of citations of the paper that reports this interaction (PubMedID 22779921)
9

Data Source:
BioGRID (two hybrid)

		HMGN1	SPP1
Description		high mobility group nucleosome binding domain 1	secreted phosphoprotein 1
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	DNA Binding Nucleosomal DNA Binding	Cytokine Activity Integrin Binding Protein Binding Extracellular Matrix Binding
	Biological Process	Pyrimidine Dimer Repair By Nucleotide-excision Repair Transcription-coupled Nucleotide-excision Repair Chromatin Organization Regulation Of Transcription By RNA Polymerase II Response To UV-B Response To UV-C Positive Regulation Of DNA-templated Transcription, Elongation Regulation Of Development, Heterochronic Post-embryonic Camera-type Eye Morphogenesis Regulation Of Epithelial Cell Proliferation Positive Regulation Of NAD+ ADP-ribosyltransferase Activity	Osteoblast Differentiation Androgen Catabolic Process Inflammatory Response Cell Adhesion Signal Transduction Embryo Implantation Extracellular Matrix Organization Biomineral Tissue Development Response To Vitamin D Post-translational Protein Modification Cellular Protein Metabolic Process Positive Regulation Of Bone Resorption Positive Regulation Of Transcription, DNA-templated Decidualization Response To Steroid Hormone Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Cellular Response To Testosterone Stimulus Positive Regulation Of Estradiol Secretion
Pathways		Formation of TC-NER Pre-Incision Complex Transcription-Coupled Nucleotide Excision Repair (TC-NER) Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER	Degradation of the extracellular matrix Signaling by PDGF Integrin cell surface interactions Integrin cell surface interactions Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) RUNX3 Regulates Immune Response and Cell Migration Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Smoking status (ever vs never smokers) ( 30643258)	Blood protein levels ( 30072576) Dental caries ( 23064961) Urate levels ( 31578528)
Interacting Genes		20 interacting genes: CHEK2 EP300 HMGN2 HPF1 IRF2 LIG4 MDM2 NFE2 PARP1 PPP1CC PRKACA PRKACG PRKCA RPS6KA3 RPS6KA4 RPS6KA5 SLC38A3 SPP1 TERF2 YWHAZ	89 interacting genes: ABCF3 ACP5 AFF4 AMOTL2 APOA1 ATP2A2 ATP5PB BAG6 BRD3 C1RL C2orf50 CACNG4 CALM1 CC2D1B CD44 CEP162 CHD1 CISD2 CMTM3 COMMD1 COPS5 CSNK2A1 CSNK2A2 CTNNBL1 CYB5R3 DCX DNAJB1 DNTTIP2 DSEL EEF1A1 EIF3K EPAS1 F2 FTH1 GRIPAP1 HBA2 HMGN1 IGFBP5 ITGA5 ITGA9 ITGAV ITGB1 ITGB5 KCNIP1 LRRC4 MAP1A MAP1B MARCKS MEOX2 MMP3 MMP7 MPPED1 MRPL23 NACA NCKAP1 NCSTN PDLIM7 PEMT PEPD PLD3 PRKACB PRKCA PRKG1 RANBP9 RAPGEF2 RBBP6 RIMS4 RPL13 RPL15 RPL5 RPS13 SEC24C SGTA SLC39A6 SNAPIN SSB STAU1 STK39 TBC1D8 TMEM168 TMEM30A TPT1 TTC1 TUBB UBQLN4 USP42 USP8 ZNF638 ZNF804A
Entrez ID		3150	6696
HPRD ID		01231	01325
Ensembl ID		ENSG00000205581	ENSG00000118785
Uniprot IDs		P05114 Q6NSG7	A0A024RDE2 A0A024RDE6 A0A024RDJ0 B7Z351 P10451 Q3LGB0
PDB IDs			3CXD 3DSF
Enriched GO Terms of Interacting Partners?
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