KCNIP3 and PCBD2

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		KCNIP3	PCBD2
Description		potassium voltage-gated channel interacting protein 3	pterin-4 alpha-carbinolamine dehydratase 2
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GO Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Golgi Apparatus Cytosol Plasma Membrane Voltage-gated Potassium Channel Complex Dendrite Protein-DNA Complex Axon Terminus	Cellular_component Nucleus
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Transcription Corepressor Activity Voltage-gated Ion Channel Activity Potassium Channel Activity Calcium Ion Binding Protein Binding Potassium Channel Regulator Activity Ion Channel Binding	Phenylalanine 4-monooxygenase Activity Protein Binding 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Identical Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Intracellular Protein Transport Apoptotic Process Signal Transduction Cardiac Conduction Potassium Ion Transmembrane Transport Protein Localization To Plasma Membrane Regulation Of Potassium Ion Transmembrane Transport	Tetrahydrobiopterin Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Oxidation-reduction Process
Pathways		Phase 1 - inactivation of fast Na+ channels
Drugs
Diseases
GWAS		Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	Bulimia nervosa ( 23568457) Colorectal cancer ( 23263487) Height ( 28552196 18391951) Type 2 diabetes ( 24509480)
Interacting Genes		18 interacting genes: CALM2 CASP3 CD177 CLN3 CREB1 CREM CTBP2 GRK2 GRK6 IGF1R IGLV3-25 IL6ST MAVS PCBD2 PPP3CA PSEN1 PSEN2 TARBP2	33 interacting genes: AATF APP ASCC2 BRF1 C1D CDC5L CENPK CHAF1A F2RL1 FBXO7 GTF2E1 HES4 IRF2BP1 KCNIP3 MAGEA11 MED21 MED30 MED4 MED7 MET PBXIP1 PCBD1 PHF14 PML RUNX1T1 SNW1 SSX3 SSX5 STAT3 TAL2 TGIF2LY XBP1 ZZZ3
Entrez ID		30818	84105
HPRD ID		05232	17824
Ensembl ID		ENSG00000115041	ENSG00000132570
Uniprot IDs		A0A024RE22 Q9Y2W7	Q9H0N5
PDB IDs		2E6W	4C45
Enriched GO Terms of Interacting Partners?
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