SLC25A6 and KARS1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		SLC25A6	KARS1
Description		solute carrier family 25 member 6	lysyl-tRNA synthetase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Mitochondrion Mitochondrial Inner Membrane TIM23 Mitochondrial Import Inner Membrane Translocase Complex Integral Component Of Membrane	Extracellular Space Nucleus Mitochondrion Mitochondrial Matrix Cytosol Plasma Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex
	Molecular Function	ATP:ADP Antiporter Activity Protein Binding	TRNA Binding ATP Adenylyltransferase Activity Lysine-tRNA Ligase Activity Protein Binding ATP Binding Amino Acid Binding Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Protein Targeting To Mitochondrion Apoptotic Process ADP Transport ATP Transport Viral Process Regulation Of Insulin Secretion Transmembrane Transport	Activation Of MAPK Activity Basophil Activation Involved In Immune Response Positive Regulation Of Cytokine Secretion Involved In Immune Response TRNA Aminoacylation For Protein Translation Lysyl-tRNA Aminoacylation TRNA Processing Negative Regulation Of Cell Proliferation Response To X-ray Positive Regulation Of Macrophage Chemotaxis Diadenosine Tetraphosphate Biosynthetic Process Viral Process Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Macrophage Activation Positive Regulation Of Transcription, DNA-templated ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of P38MAPK Cascade Positive Regulation Of Metallopeptidase Activity
Pathways		Mitochondrial protein import Mitochondrial protein import Influenza Virus Induced Apoptosis Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	Selenoamino acid metabolism Cytosolic tRNA aminoacylation Mitochondrial tRNA aminoacylation
Drugs		Clodronic Acid	L-Lysine
Diseases			Charcot-Marie-Tooth disease (CMT); Hereditary motor and sensory neuropathy; Peroneal muscular atrophy
GWAS
Interacting Genes		19 interacting genes: AP2B1 CHEK2 CHGB FGFR3 KARS1 KRT31 KRTAP4-12 LZTS2 MID2 MTUS2 NOTCH2NLA PLSCR1 PRSS23 STRN4 TEKT4 TRAF1 TRIM23 TRIP6 VIM	16 interacting genes: AIMP2 DARS2 EEF1D EEF1G ESR1 FRS3 GAPDH GEMIN4 MAPK1 PAFAH1B1 PIK3R3 RPSA SLC25A6 SOD1 SPTAN1 VIM
Entrez ID		293	3735
HPRD ID		02461	03249
Ensembl ID		ENSG00000169100	ENSG00000065427
Uniprot IDs		P12236 Q6I9V5	Q15046
PDB IDs			3BJU 4DPG 4YCU 4YCW 6CHD 6ILD 6ILH
Enriched GO Terms of Interacting Partners?
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