UHRF1 and LASP1

Number of citations of the paper that reports this interaction (PubMedID 25982273)
12

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		UHRF1	LASP1
Description		ubiquitin like with PHD and ring finger domains 1	LIM and SH3 protein 1
Image
GO Annotations	Cellular Component	Nuclear Chromatin Euchromatin Heterochromatin Nucleus Nucleoplasm Replication Fork Nuclear Heterochromatin Nuclear Matrix	Cytoplasm Focal Adhesion Cortical Actin Cytoskeleton
	Molecular Function	Proximal Promoter Sequence-specific DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Methyl-CpG Binding Nucleosomal Histone Binding Methylated Histone Binding Histone Binding Identical Protein Binding Hemi-methylated DNA-binding Ubiquitin Protein Ligase Activity	SH3/SH2 Adaptor Activity Protein Binding Ion Transmembrane Transporter Activity Cadherin Binding Metal Ion Binding Actin Filament Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Repair Ubiquitin-dependent Protein Catabolic Process Cell Cycle Maintenance Of DNA Methylation Histone Monoubiquitination Protein Ubiquitination Histone Ubiquitination Positive Regulation Of Cellular Protein Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Epithelial Cell Proliferation Protein Autoubiquitination Positive Regulation Of DNA Topoisomerase (ATP-hydrolyzing) Activity	Ion Transport Positive Regulation Of Signal Transduction Ion Transmembrane Transport
Pathways		DNA methylation
Drugs
Diseases
GWAS		Birth weight ( 31043758) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Mental health study participation (completed survey) ( 31263887) Systolic blood pressure ( 30578418) Type 2 diabetes ( 30297969) Urate levels ( 31578528)	Cognitive decline rate in late mild cognitive impairment ( 26252872) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912)
Interacting Genes		25 interacting genes: DNMT3A ERCC1 ERG FANCD2 H2AC4 H2BC3 H3-4 H3C1 H3C13 H3C14 H3C15 H4C14 KAT5 LASP1 LIG1 MBD4 MUS81 PARP1 PCNA PRKACA TP53 UBE2D1 UBE2D3 UBE2N UHRF2	40 interacting genes: ACD ACTA1 ACTB ACTC1 ARHGEF15 ATXN1 CDK7 COPS5 CRK DAZAP2 DNMT1 EHMT2 FHL3 FXR2 GOLGA2 KRTAP4-2 LZTS2 MDFI PLSCR1 POT1 PRKAR2B PRKG1 PRKG2 PSMA3 RBPMS REL RHOXF2 SEPTIN3 SPRY2 STAT3 TCF4 TERF1 THAP1 TINF2 TRIM27 TRIP13 UHRF1 ZBTB9 ZC2HC1A ZYX
Entrez ID		29128	3927
HPRD ID		06992	04229
Ensembl ID		ENSG00000276043	ENSG00000002834
Uniprot IDs		A0A087WVR3 Q96T88	A0A024R1S8 B4DIC4 Q14847
PDB IDs		2FAZ 2L3R 2LGG 2LGK 2LGL 2PB7 3ASK 3ASL 3BI7 3CLZ 3DB3 3DB4 3DWH 3FL2 3SHB 3SOU 3SOW 3SOX 3T6R 3ZVY 3ZVZ 4GY5 4QQD 5C6D 5IAY 5XPI 5YY9 5YYA 6B9M 6IIW	3I35
Enriched GO Terms of Interacting Partners?
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