ANKRD11 and HDAC5

Number of citations of the paper that reports this interaction (PubMedID 15184363)
29

Data Source:
HPRD (in vitro)

		ANKRD11	HDAC5
Description		ankyrin repeat domain 11	histone deacetylase 5
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Nuclear Speck
	Molecular Function		RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding Chromatin Binding Histone Deacetylase Activity Protein Kinase C Binding Protein Binding Transcription Factor Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Histone Deacetylase Binding Transcription Regulatory Region DNA Binding Metal Ion Binding Repressing Transcription Factor Binding
	Biological Process	In Utero Embryonic Development Tissue Homeostasis Anatomical Structure Morphogenesis Multicellular Organism Growth Odontogenesis Of Dentin-containing Tooth Skeletal System Morphogenesis Face Morphogenesis Bone Development	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Chromatin Silencing Protein Deacetylation Inflammatory Response Regulation Of Myotube Differentiation Negative Regulation Of Myotube Differentiation Response To Activity Histone Deacetylation Neuron Differentiation B Cell Differentiation Cellular Response To Insulin Stimulus Regulation Of Gene Expression, Epigenetic B Cell Activation Response To Cocaine Regulation Of Protein Binding Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Histone H3 Deacetylation Cellular Response To Lipopolysaccharide Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Histone H3-K9 Acetylation
Pathways			NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway Regulation of PTEN gene transcription
Drugs			Belinostat Panobinostat
Diseases
GWAS		Lymphocyte counts ( 27863252)	Bipolar disorder ( 31043756) Bone mineral density (hip) ( 19801982) Bone mineral density (spine) ( 19801982) Heel bone mineral density ( 30598549 28869591)
Interacting Genes		21 interacting genes: CDCA7L CEP44 GOLGA2 HDAC3 HDAC4 HDAC5 HOOK2 HRAS IKZF1 LZTS2 MKRN3 NCOA1 NCOA2 NCOA3 PDE4DIP RAC3 SRC TFIP11 TRAF2 TRIM37 TSPOAP1	60 interacting genes: ANKRA2 ANKRD11 ATF3 BCL6 BCOR BRMS1 CAMK1 CAMTA2 CBX5 CIITA CTBP1 DDX20 DYRK1B EEF1G ESR1 GABARAP GATA1 GATA2 GCM1 GNB1 H3C1 HDAC3 HDAC7 HIF1A HOXC11 HR JDP2 KLF4 MAFF MEF2A MEF2C MEF2D NCOR1 NCOR2 NFATC1 NFKB2 NFKBIE NRIP1 PHB2 PKN1 PKN2 PRKAA1 PRKCD PRKD1 RFXANK RUNX3 SFN SIK1 SIK2 SIK3 SLC2A4RG SMAD3 SUV39H1 TAB2 UBC UBE2I YWHAB YWHAE YWHAQ ZBTB16
Entrez ID		29123	10014
HPRD ID		12456	09246
Ensembl ID		ENSG00000167522	ENSG00000108840
Uniprot IDs		Q6UB99	Q9UQL6
PDB IDs			5UWI
Enriched GO Terms of Interacting Partners?
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