HDAC5 and PHB2

Number of citations of the paper that reports this interaction (PubMedID 15140878)
41

Data Source:
HPRD (in vivo, in vitro)

		HDAC5	PHB2
Description		histone deacetylase 5	prohibitin 2
Image
GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Nuclear Speck	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Cell Surface Postsynaptic Density Nuclear Matrix Axon Protein-containing Complex Presynaptic Active Zone Cell Periphery Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding Chromatin Binding Histone Deacetylase Activity Protein Kinase C Binding Protein Binding Transcription Factor Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Histone Deacetylase Binding Transcription Regulatory Region DNA Binding Metal Ion Binding Repressing Transcription Factor Binding	Protein Binding Protein C-terminus Binding Estrogen Receptor Binding Amide Binding Sphingolipid Binding Protein N-terminus Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Chromatin Silencing Protein Deacetylation Inflammatory Response Regulation Of Myotube Differentiation Negative Regulation Of Myotube Differentiation Response To Activity Histone Deacetylation Neuron Differentiation B Cell Differentiation Cellular Response To Insulin Stimulus Regulation Of Gene Expression, Epigenetic B Cell Activation Response To Cocaine Regulation Of Protein Binding Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Histone H3 Deacetylation Cellular Response To Lipopolysaccharide Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Histone H3-K9 Acetylation	Protein Import Into Nucleus Mitochondrial Calcium Ion Transmembrane Transport Mitochondrion Organization Sister Chromatid Cohesion Response To Wounding Regulation Of Complement Activation Positive Regulation Of Exit From Mitosis Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Negative Regulation Of Apoptotic Process Negative Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Transcription, DNA-templated Protein Stabilization Positive Regulation Of DNA-binding Transcription Factor Activity Mammary Gland Branching Involved In Thelarche Mammary Gland Alveolus Development Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Retinoic Acid Cellular Response To Hypoxia Positive Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Cytochrome-c Oxidase Activity
Pathways		NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway Regulation of PTEN gene transcription	Processing of SMDT1
Drugs		Belinostat Panobinostat	Capsaicin
Diseases
GWAS		Bipolar disorder ( 31043756) Bone mineral density (hip) ( 19801982) Bone mineral density (spine) ( 19801982) Heel bone mineral density ( 30598549 28869591)	Glycated hemoglobin levels ( 28898252) Red blood cell fatty acid levels ( 25500335)
Interacting Genes		60 interacting genes: ANKRA2 ANKRD11 ATF3 BCL6 BCOR BRMS1 CAMK1 CAMTA2 CBX5 CIITA CTBP1 DDX20 DYRK1B EEF1G ESR1 GABARAP GATA1 GATA2 GCM1 GNB1 H3C1 HDAC3 HDAC7 HIF1A HOXC11 HR JDP2 KLF4 MAFF MEF2A MEF2C MEF2D NCOR1 NCOR2 NFATC1 NFKB2 NFKBIE NRIP1 PHB2 PKN1 PKN2 PRKAA1 PRKCD PRKD1 RFXANK RUNX3 SFN SIK1 SIK2 SIK3 SLC2A4RG SMAD3 SUV39H1 TAB2 UBC UBE2I YWHAB YWHAE YWHAQ ZBTB16	19 interacting genes: AFP AKT1 ESR1 EZH2 FHL2 HDAC1 HDAC2 HDAC3 HDAC5 MEF2A MYOD1 NR2F1 NR2F2 PPARG PRKCA PTMA RNF2 TEAD3 UPF2
Entrez ID		10014	11331
HPRD ID		09246	17843
Ensembl ID		ENSG00000108840	ENSG00000215021
Uniprot IDs		Q9UQL6	Q99623
PDB IDs		5UWI	6IQE
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?