HDAC5 and KLF4

Number of citations of the paper that reports this interaction (PubMedID 18768922)
70

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		HDAC5	KLF4
Description		histone deacetylase 5	Kruppel like factor 4
Image			No pdb structure
GO Annotations	Cellular Component	Histone Deacetylase Complex Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Nuclear Speck	Nuclear Chromatin Nucleus Nucleoplasm Nuclear Euchromatin Cytoplasm Nuclear Transcription Factor Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding Chromatin Binding Histone Deacetylase Activity Protein Kinase C Binding Protein Binding Transcription Factor Binding NAD-dependent Histone Deacetylase Activity (H3-K14 Specific) Protein Deacetylase Activity Histone Deacetylase Binding Transcription Regulatory Region DNA Binding Metal Ion Binding Repressing Transcription Factor Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Sequence-specific DNA-binding Transcription Factor Recruiting Activity RNA Polymerase II Transcription Factor Binding Transcription Cofactor Binding DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Beta-catenin Binding Zinc Ion Binding Phosphatidylinositol 3-kinase Regulator Activity Histone Deacetylase Binding Transcription Regulatory Region DNA Binding Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Chromatin Remodeling Chromatin Silencing Protein Deacetylation Inflammatory Response Regulation Of Myotube Differentiation Negative Regulation Of Myotube Differentiation Response To Activity Histone Deacetylation Neuron Differentiation B Cell Differentiation Cellular Response To Insulin Stimulus Regulation Of Gene Expression, Epigenetic B Cell Activation Response To Cocaine Regulation Of Protein Binding Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-binding Transcription Factor Activity Histone H3 Deacetylation Cellular Response To Lipopolysaccharide Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Regulation Of Histone H3-K9 Acetylation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Mesodermal Cell Fate Determination Negative Regulation Of Cell Proliferation Epidermal Cell Differentiation Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Negative Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Muscle Hyperplasia Negative Regulation Of Angiogenesis Stem Cell Population Maintenance Post-embryonic Camera-type Eye Development Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Cellular Protein Metabolic Process Negative Regulation Of Heterotypic Cell-cell Adhesion Somatic Stem Cell Population Maintenance Post-embryonic Hemopoiesis Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Phosphatidylinositol 3-kinase Activity Negative Regulation Of Interleukin-8 Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Fat Cell Differentiation Regulation Of Cell Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Hemoglobin Biosynthetic Process Negative Regulation Of Smooth Muscle Cell Proliferation Regulation Of Axon Regeneration Epidermis Morphogenesis Negative Regulation Of Inflammatory Response Positive Regulation Of Protein Metabolic Process Negative Regulation Of Protein Kinase B Signaling Positive Regulation Of Telomerase Activity Canonical Wnt Signaling Pathway Negative Regulation Of Response To Cytokine Stimulus Pri-miRNA Transcription By RNA Polymerase II Cellular Response To Hydrogen Peroxide Negative Regulation Of ERK1 And ERK2 Cascade Cellular Response To Retinoic Acid Cellular Response To Growth Factor Stimulus Cellular Response To Cycloheximide Cellular Response To Laminar Fluid Shear Stress Negative Regulation Of Cell Migration Involved In Sprouting Angiogenesis Cellular Response To Peptide Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Core Promoter Binding Negative Regulation Of Leukocyte Adhesion To Arterial Endothelial Cell Cellular Response To Leukemia Inhibitory Factor Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production
Pathways		NOTCH1 Intracellular Domain Regulates Transcription Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants Notch-HLH transcription pathway Regulation of PTEN gene transcription	Transcriptional regulation of white adipocyte differentiation Synthesis, secretion, and deacylation of Ghrelin Transcriptional regulation of pluripotent stem cells FOXO-mediated transcription of cell cycle genes
Drugs		Belinostat Panobinostat
Diseases
GWAS		Bipolar disorder ( 31043756) Bone mineral density (hip) ( 19801982) Bone mineral density (spine) ( 19801982) Heel bone mineral density ( 30598549 28869591)	Breast cancer ( 21263130) Colorectal or endometrial cancer ( 26621817) Cotinine glucuronidation ( 25293881) Cutaneous malignant melanoma ( 26237428) Glycated hemoglobin levels ( 28898252) Heel bone mineral density ( 30598549 28869591) Prostate cancer ( 23023329) Psoriasis ( 25574825 23143594) Psoriasis vulgaris ( 26626624) Takayasu arteritis ( 25604533) Tenofovir clearance in HIV infection ( 26148204)
Interacting Genes		60 interacting genes: ANKRA2 ANKRD11 ATF3 BCL6 BCOR BRMS1 CAMK1 CAMTA2 CBX5 CIITA CTBP1 DDX20 DYRK1B EEF1G ESR1 GABARAP GATA1 GATA2 GCM1 GNB1 H3C1 HDAC3 HDAC7 HIF1A HOXC11 HR JDP2 KLF4 MAFF MEF2A MEF2C MEF2D NCOR1 NCOR2 NFATC1 NFKB2 NFKBIE NRIP1 PHB2 PKN1 PKN2 PRKAA1 PRKCD PRKD1 RFXANK RUNX3 SFN SIK1 SIK2 SIK3 SLC2A4RG SMAD3 SUV39H1 TAB2 UBC UBE2I YWHAB YWHAE YWHAQ ZBTB16	13 interacting genes: APP CREBBP ELK1 EP300 FBXO7 HDAC1 HDAC5 KAT5 KLF6 SETD7 SP1 TP53 VHL
Entrez ID		10014	9314
HPRD ID		09246	03769
Ensembl ID		ENSG00000108840	ENSG00000136826
Uniprot IDs		Q9UQL6	O43474
PDB IDs		5UWI
Enriched GO Terms of Interacting Partners?
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