MYLIP and MTAP

Number of citations of the paper that reports this interaction (PubMedID 12826659)
20

Data Source:
HPRD (in vitro, two hybrid)

		MYLIP	MTAP
Description		myosin regulatory light chain interacting protein	methylthioadenosine phosphorylase
Image
GO Annotations	Cellular Component	Cytosol Plasma Membrane	Nucleus Cytoplasm Cytosol Extracellular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Cytoskeletal Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Phosphorylase Activity Purine-nucleoside Phosphorylase Activity Protein Binding S-methyl-5-thioadenosine Phosphorylase Activity
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Nervous System Development Negative Regulation Of Neuron Projection Development Negative Regulation Of Low-density Lipoprotein Particle Clearance Protein Ubiquitination Protein Destabilization Low-density Lipoprotein Particle Receptor Catabolic Process Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Cholesterol Homeostasis Positive Regulation Of Protein Catabolic Process	Nucleobase-containing Compound Metabolic Process Purine Ribonucleoside Salvage Nicotinamide Riboside Catabolic Process L-methionine Salvage From Methylthioadenosine Methylation Response To Testosterone Interleukin-12-mediated Signaling Pathway
Pathways		VLDLR internalisation and degradation NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake Antigen processing: Ubiquitination & Proteasome degradation	Methionine salvage pathway Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Drugs			Adenine (1s)-1-(9-Deazaadenin-9-Yl)-1,4,5-Trideoxy-1,4-Imino-5-Methylthio-D-Ribitol Formycin 5'-Deoxy-5'-Methylthioadenosine 5'-Deoxy-5'-(Methylthio)-Tubercidin
Diseases
GWAS		Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Cholesterol, total ( 24097068) Diisocyanate-induced asthma ( 25918132) Femoral neck bone mineral density ( 30172743) LDL cholesterol ( 24097068 20864672 25961943) LDL cholesterol levels ( 28334899 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Major depressive disorder ( 23377640) Medication use (HMG CoA reductase inhibitors) ( 31015401) Response to statins (LDL cholesterol change) ( 22331829) Total cholesterol levels ( 28334899)	Adverse response to drug ( 30420678) Coronary artery calcified atherosclerotic plaque (130 HU threshold) in type 2 diabetes ( 29221444) Coronary heart disease ( 21606135) Cutaneous nevi ( 19578365) Diastolic blood pressure ( 28135244) Diastolic blood pressure response to hydrochlorothiazide in hypertension ( 27802415) Glycated hemoglobin levels ( 28898252) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Lung cancer in never smokers ( 28604730) Lung function in heavy smokers (low FEV1 vs high FEV1) ( 26423011) Macular thickness ( 30535121) Melanoma ( 21983787 28212542) Nevus count ( 30429480) Nevus count or cutaneous melanoma ( 30429480) Pediatric bone mineral content (radius) ( 26041818) Pulse pressure ( 28135244)
Interacting Genes		18 interacting genes: AR CNPY2 CRK DAPP1 KDM1A LNX2 LRP8 MIPOL1 MTAP MYL12B RASSF5 SRPK2 TSC22D4 UBE2D2 UBE2D3 UBE2D4 UBE2N VLDLR	6 interacting genes: CDC25A CENPH FOLH1 LYRM1 MYLIP RELB
Entrez ID		29116	4507
HPRD ID		17621	01134
Ensembl ID		ENSG00000007944	ENSG00000099810
Uniprot IDs		Q5TIA5 Q8WY64	A0A384ME80 Q13126
PDB IDs		2YHN 2YHO	1CB0 1CG6 1K27 1SD1 1SD2 3LN5 3OZC 3OZD 3OZE 5EUB 5TC5 5TC6 5TC7 5TC8 6DYZ 6DZ0 6DZ2 6DZ3
Enriched GO Terms of Interacting Partners?
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