MYLIP and MYL12B

Number of citations of the paper that reports this interaction (PubMedID 10593918)
24

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (in vivo, two hybrid)

		MYLIP	MYL12B
Description		myosin regulatory light chain interacting protein	myosin light chain 12B
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane	Stress Fiber Cytosol Brush Border Myosin II Complex Z Disc Apical Part Of Cell Extracellular Exosome Cell Cortex Region
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Cytoskeletal Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Calcium Ion Binding Protein Binding Myosin Heavy Chain Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Nervous System Development Negative Regulation Of Neuron Projection Development Negative Regulation Of Low-density Lipoprotein Particle Clearance Protein Ubiquitination Protein Destabilization Low-density Lipoprotein Particle Receptor Catabolic Process Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Cholesterol Homeostasis Positive Regulation Of Protein Catabolic Process	Muscle Contraction Regulation Of Cell Shape
Pathways		VLDLR internalisation and degradation NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake Antigen processing: Ubiquitination & Proteasome degradation	EPHA-mediated growth cone collapse Sema4D induced cell migration and growth-cone collapse Smooth Muscle Contraction RHO GTPases activate PKNs RHO GTPases activate CIT RHO GTPases Activate ROCKs RHO GTPases activate PAKs RHO GTPases activate PAKs
Drugs
Diseases
GWAS		Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Cholesterol, total ( 24097068) Diisocyanate-induced asthma ( 25918132) Femoral neck bone mineral density ( 30172743) LDL cholesterol ( 24097068 20864672 25961943) LDL cholesterol levels ( 28334899 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Major depressive disorder ( 23377640) Medication use (HMG CoA reductase inhibitors) ( 31015401) Response to statins (LDL cholesterol change) ( 22331829) Total cholesterol levels ( 28334899)	Response to methotrexate in juvenile idiopathic arthritis ( 24709693)
Interacting Genes		18 interacting genes: AR CNPY2 CRK DAPP1 KDM1A LNX2 LRP8 MIPOL1 MTAP MYL12B RASSF5 SRPK2 TSC22D4 UBE2D2 UBE2D3 UBE2D4 UBE2N VLDLR	4 interacting genes: DAPK1 HSPB1 MYLIP PNKD
Entrez ID		29116	103910
HPRD ID		17621	10095
Ensembl ID		ENSG00000007944	ENSG00000118680
Uniprot IDs		Q5TIA5 Q8WY64	O14950
PDB IDs		2YHN 2YHO
Enriched GO Terms of Interacting Partners?
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