MYLIP and MIPOL1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		MYLIP	MIPOL1
Description		myosin regulatory light chain interacting protein	mirror-image polydactyly 1
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane	Nucleus
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Cytoskeletal Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding Identical Protein Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Nervous System Development Negative Regulation Of Neuron Projection Development Negative Regulation Of Low-density Lipoprotein Particle Clearance Protein Ubiquitination Protein Destabilization Low-density Lipoprotein Particle Receptor Catabolic Process Regulation Of Low-density Lipoprotein Particle Receptor Catabolic Process Cholesterol Homeostasis Positive Regulation Of Protein Catabolic Process
Pathways		VLDLR internalisation and degradation NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Asthma exacerbations in inhaled corticosteroid treatment ( 30697902) Cholesterol, total ( 24097068) Diisocyanate-induced asthma ( 25918132) Femoral neck bone mineral density ( 30172743) LDL cholesterol ( 24097068 20864672 25961943) LDL cholesterol levels ( 28334899 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Major depressive disorder ( 23377640) Medication use (HMG CoA reductase inhibitors) ( 31015401) Response to statins (LDL cholesterol change) ( 22331829) Total cholesterol levels ( 28334899)	Estimated glomerular filtration rate ( 31152163) Intraocular pressure ( 29617998) Longitudinal alcohol consumption ( 26081443) Mean corpuscular hemoglobin ( 27863252) Mean corpuscular volume ( 27863252) Metabolite levels ( 23823483) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Tonsillectomy ( 27182965 28928442)
Interacting Genes		18 interacting genes: AR CNPY2 CRK DAPP1 KDM1A LNX2 LRP8 MIPOL1 MTAP MYL12B RASSF5 SRPK2 TSC22D4 UBE2D2 UBE2D3 UBE2D4 UBE2N VLDLR	38 interacting genes: ARNT2 ATP5PO BEX2 BYSL CCDC33 CCT3 CDK18 CKS1B DGCR6 EAF1 EIF4E2 ENKD1 FAM161A FBF1 HAUS1 MAGEA6 MCM7 MFAP1 MYLIP NEBL PPP1R13B PRPF31 RBM41 RCOR3 RNF6 RPL10L RTP5 SCNM1 SMARCE1 SRPK2 SSX3 TCHP TTC12 UBE2K USH1C UTP25 ZGPAT ZNF688
Entrez ID		29116	145282
HPRD ID		17621	06029
Ensembl ID		ENSG00000007944	ENSG00000151338
Uniprot IDs		Q5TIA5 Q8WY64	A8K735 G5EA54 Q4G0U7 Q8TD10
PDB IDs		2YHN 2YHO
Enriched GO Terms of Interacting Partners?
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