TRIM59 and VTI1B

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		TRIM59	VTI1B
Description		tripartite motif containing 59	vesicle transport through interaction with t-SNAREs 1B
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Intraciliary Transport Particle B	Extracellular Region Lysosomal Membrane Endoplasmic Reticulum Membrane Golgi Apparatus Cytosol Synaptic Vesicle ER To Golgi Transport Vesicle Membrane Integral Component Of Membrane Platelet Alpha Granule Lumen SNARE Complex Early Endosome Membrane Late Endosome Membrane Vesicle Neuronal Cell Body Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Recycling Endosome Recycling Endosome Membrane
	Molecular Function	Protein Binding Zinc Ion Binding	SNARE Binding SNAP Receptor Activity Protein Binding Chloride Channel Inhibitor Activity
	Biological Process	Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response	Platelet Degranulation Protein Targeting To Vacuole ER To Golgi Vesicle-mediated Transport Intra-Golgi Vesicle-mediated Transport Golgi To Vacuole Transport Vesicle Docking Involved In Exocytosis Vesicle-mediated Transport Retrograde Transport, Endosome To Golgi Vesicle Fusion With Golgi Apparatus Membrane Fusion Autophagosome Maturation Regulation Of Protein Localization To Plasma Membrane
Pathways			Platelet degranulation
Drugs
Diseases
GWAS		Alcohol use disorder (total score) ( 30336701) Bipolar disorder ( 31043756) Intrinsic epigenetic age acceleration ( 29374233) Pulse pressure ( 30578418) Systolic blood pressure ( 30578418)	Blood protein levels ( 30072576)
Interacting Genes		9 interacting genes: ECSIT ESR1 ESR2 NRM OTOL1 PPM1L RHOU VTI1B ZDHHC22	13 interacting genes: CLINT1 CREB3 GOLGB1 KRTAP10-7 LDLRAD1 LMNA PTPN5 STX4 STX7 STX8 SYNE4 TNK2 TRIM59
Entrez ID		286827	10490
HPRD ID		15568	04440
Ensembl ID		ENSG00000213186	ENSG00000100568
Uniprot IDs		Q8IWR1	Q9UEU0
PDB IDs			2V8S
Enriched GO Terms of Interacting Partners?
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