ERICH2 and MACROH2A1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		ERICH2	MACROH2A1
Description		glutamate rich 2	macroH2A.1 histone
Image		No pdb structure
GO Annotations	Cellular Component		Nuclear Chromosome Nuclear Chromosome, Telomeric Region Nucleosome Nuclear Chromatin Condensed Chromosome Sex Chromatin Barr Body Nucleus Nucleoplasm Pericentric Heterochromatin Nucleolus Extracellular Exosome
	Molecular Function	Protein Binding	RDNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA Binding Protein Binding Double-stranded Methylated DNA Binding Enzyme Binding Protein Kinase Binding Protein Serine/threonine Kinase Inhibitor Activity Chromatin DNA Binding Nucleosomal DNA Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity Promoter-specific Chromatin Binding
	Biological Process		Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Nucleosome Assembly Chromatin Silencing Dosage Compensation Regulation Of Lipid Metabolic Process Negative Regulation Of Histone Phosphorylation Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Regulation Of Gene Expression, Epigenetic Positive Regulation Of Keratinocyte Differentiation Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Gene Expression, Epigenetic Negative Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K27 Methylation Regulation Of Chromatin Silencing At RDNA Establishment Of Protein Localization To Chromatin Negative Regulation Of Protein Serine/threonine Kinase Activity Negative Regulation Of Transcription Of Nucleolar Large RRNA By RNA Polymerase I Negative Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Response To Oxidative Stress Negative Regulation Of Protein Localization To Chromosome, Telomeric Region
Pathways
Drugs
Diseases
GWAS		Metabolic syndrome ( 31589552)
Interacting Genes		4 interacting genes: FBXO7 IWS1 MACROH2A1 SDCBP	9 interacting genes: APP ATF2 ATXN1L BARD1 BRCA1 ERICH2 PARP1 SPOP SRPK1
Entrez ID		285141	9555
HPRD ID			13624
Ensembl ID		ENSG00000204334	ENSG00000113648
Uniprot IDs		A1L162	O75367
PDB IDs			1U35 1ZR3 1ZR5 2F8N 2FXK 3HQH 3HSV 3IID 3IIF 3IVB 5IIT 5LNC
Enriched GO Terms of Interacting Partners?
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