CCDC57 and SFI1

Number of citations of the paper that reports this interaction (PubMedID 21516116)
94

Data Source:
BioGRID (two hybrid)

		CCDC57	SFI1
Description		coiled-coil domain containing 57	SFI1 centrin binding protein
Image		No pdb structure
GO Annotations	Cellular Component		Centrosome Centriole Cytosol
	Molecular Function	Protein Binding	Protein Binding Phosphatase Binding
	Biological Process		G2/M Transition Of Mitotic Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Phosphatase Activity Ciliary Basal Body-plasma Membrane Docking
Pathways			Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Blood metabolite levels ( 24816252) Blood urea nitrogen levels ( 31152163) Proteinuria and chronic kidney disease ( 26420894)	Age-related hearing impairment ( 24939585) Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Metabolite levels ( 23823483) Type 2 diabetes ( 31118516)
Interacting Genes		46 interacting genes: AQP1 ARL4A AXIN1 CBX8 CCDC120 CDC20B CEP57L1 CWF19L2 ECPAS FAM161A FAM50B FAM90A1 GPKOW HAUS1 HBA2 LENG1 LINC00526 MFAP1 NAPRT NELFE NUMA1 PER1 PPHLN1 PPP1R18 PRAM1 PRPF31 PRR3 PTPN7 RAB3IL1 RNF6 ROBO3 RXRB SFI1 SIRPA TBC1D22B TLE5 TMEM100 TSGA10IP USP15 USP2 UTP14C ZFC3H1 ZGPAT ZMAT2 ZNF417 ZNF688	14 interacting genes: CCDC120 CCDC57 CETN2 CRX FAM131C GCSH GOLGA2 KRT19 LPXN MAD2L2 MDFI RADIL RBPMS SERTAD1
Entrez ID		284001	9814
HPRD ID		14150	11550
Ensembl ID		ENSG00000176155	ENSG00000198089
Uniprot IDs		A0A590UJT6 Q2TAC2	A8K8P3
PDB IDs			2K2I
Enriched GO Terms of Interacting Partners?
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