CCDC57 and RXRB

Number of citations of the paper that reports this interaction (PubMedID 26871637)
108

Data Source:
BioGRID (two hybrid)

		CCDC57	RXRB
Description		coiled-coil domain containing 57	retinoid X receptor beta
Image		No pdb structure
GO Annotations	Cellular Component		Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm RNA Polymerase II Transcription Factor Complex
	Molecular Function	Protein Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Transcription Coactivator Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Retinoic Acid-responsive Element Binding
	Biological Process		Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Cell Differentiation Response To Retinoic Acid Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Anatomical Structure Development
Pathways			PPARA activates gene expression Nuclear Receptor transcription pathway Signaling by Retinoic Acid NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis
Drugs			Adapalene Bexarotene Rosiglitazone Acitretin Alitretinoin Tretinoin Tazarotene Etretinate Bezafibrate 6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-Tetrahydronaphthalen-2-Yl)Cyclopropyl]Pyridine-3-Carboxylic Acid Phthalic Acid Doconexent N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE N-(TERT-BUTYL)-3,5-DIMETHYL-N'-[(5-METHYL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)CARBONYL]BENZOHYDRAZIDE (2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID
Diseases
GWAS		Blood metabolite levels ( 24816252) Blood urea nitrogen levels ( 31152163) Proteinuria and chronic kidney disease ( 26420894)	Wegener's granulomatosis ( 23740775)
Interacting Genes		46 interacting genes: AQP1 ARL4A AXIN1 CBX8 CCDC120 CDC20B CEP57L1 CWF19L2 ECPAS FAM161A FAM50B FAM90A1 GPKOW HAUS1 HBA2 LENG1 LINC00526 MFAP1 NAPRT NELFE NUMA1 PER1 PPHLN1 PPP1R18 PRAM1 PRPF31 PRR3 PTPN7 RAB3IL1 RNF6 ROBO3 RXRB SFI1 SIRPA TBC1D22B TLE5 TMEM100 TSGA10IP USP15 USP2 UTP14C ZFC3H1 ZGPAT ZMAT2 ZNF417 ZNF688	45 interacting genes: AKAP13 CACNA1B CALCOCO2 CCDC57 EXOSC8 GOLGA2 GTF2H1 KRT40 MAP4 MID2 NCOA1 NCOA3 NR0B2 NR1H2 NR1H3 NR1H4 NR1I2 NR2C2 NR2E3 NR3C1 NR4A2 NRIP1 PLSCR1 PPARD PPARG PSTPIP1 PTMS RARA RARB RARG SIAH1 SPOP TACC2 TADA3 TAF11 TFCP2 TFIP11 THRA THRB TP53BP2 TRIM27 TRIM37 UBL7 VDR ZDHHC12
Entrez ID		284001	6257
HPRD ID		14150	01578
Ensembl ID		ENSG00000176155	ENSG00000204231
Uniprot IDs		A0A590UJT6 Q2TAC2	A0A0G2JKR7 A0A0S2Z570 B7Z7J5 P28702 Q5STP9
PDB IDs			1H9U 1UHL 5HJP 5I4V 5KYA 5KYJ
Enriched GO Terms of Interacting Partners?
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