SFI1 and GCSH

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		SFI1	GCSH
Description		SFI1 centrin binding protein	glycine cleavage system protein H
Image			No pdb structure
GO Annotations	Cellular Component	Centrosome Centriole Cytosol	Mitochondrion Mitochondrial Matrix Glycine Cleavage Complex
	Molecular Function	Protein Binding Phosphatase Binding	Aminomethyltransferase Activity Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Phosphatase Activity Ciliary Basal Body-plasma Membrane Docking	Glycine Catabolic Process Protein Lipoylation Glycine Decarboxylation Via Glycine Cleavage System
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	Glyoxylate metabolism and glycine degradation Glycine degradation
Drugs			Glycine 6-(Hydroxyethyldithio)-8-(Aminomethylthio)Octanoic Acid Dihydrolipoic Acid
Diseases			Nonketotic hyperglycinemia; Glycine encephalopathy (GCE)
GWAS		Age-related hearing impairment ( 24939585) Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Metabolite levels ( 23823483) Type 2 diabetes ( 31118516)	Glycine levels ( 31070104 30837465) Metabolite levels (small molecules and protein measures) ( 27005778) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		14 interacting genes: CCDC120 CCDC57 CETN2 CRX FAM131C GCSH GOLGA2 KRT19 LPXN MAD2L2 MDFI RADIL RBPMS SERTAD1	4 interacting genes: ING5 NMI SFI1 ZBTB16
Entrez ID		9814	2653
HPRD ID		11550	01998
Ensembl ID		ENSG00000198089	ENSG00000140905
Uniprot IDs		A8K8P3	P23434
PDB IDs		2K2I
Enriched GO Terms of Interacting Partners?
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