RXRB and RARB

Number of citations of the paper that reports this interaction (PubMedID 26871637)
108

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid, in vitro)

		RXRB	RARB
Description		retinoid X receptor beta	retinoic acid receptor beta
Image
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm RNA Polymerase II Transcription Factor Complex	Nuclear Chromatin Nucleus Nucleoplasm Cytoplasm RNA Polymerase II Transcription Factor Complex
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Transcription Coactivator Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Retinoic Acid-responsive Element Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Steroid Hormone Receptor Activity Nuclear Receptor Activity Transcription Factor Binding Drug Binding Zinc Ion Binding Nuclear Receptor Transcription Coactivator Activity Signaling Receptor Activity Protein-containing Complex Binding Retinoid X Receptor Binding Transcription Factor Activity, Direct Ligand Regulated Sequence-specific DNA Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Cell Differentiation Response To Retinoic Acid Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Retinoic Acid Receptor Signaling Pathway Anatomical Structure Development	Negative Regulation Of Transcription By RNA Polymerase II Ureteric Bud Development Liver Development Glandular Epithelial Cell Development Outflow Tract Septum Morphogenesis Growth Plate Cartilage Development Transcription Initiation From RNA Polymerase II Promoter Signal Transduction Multicellular Organism Development Negative Regulation Of Cell Proliferation Hormone-mediated Signaling Pathway Striatum Development Cell Differentiation Regulation Of Myelination Negative Regulation Of Chondrocyte Differentiation Response To Retinoic Acid Response To Lipid Embryonic Hindlimb Morphogenesis Multicellular Organism Growth Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Neuron Differentiation Positive Regulation Of Transcription By RNA Polymerase II Embryonic Eye Morphogenesis Retinoic Acid Receptor Signaling Pathway Embryonic Digestive Tract Development Embryonic Organ Development Gland Development Ventricular Cardiac Muscle Cell Differentiation Bone Morphogenesis Epithelium Development Cellular Response To Retinoic Acid
Pathways		PPARA activates gene expression Nuclear Receptor transcription pathway Signaling by Retinoic Acid NR1H2 & NR1H3 regulate gene expression linked to lipogenesis NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis	Nuclear Receptor transcription pathway Signaling by Retinoic Acid Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs		Adapalene Bexarotene Rosiglitazone Acitretin Alitretinoin Tretinoin Tazarotene Etretinate Bezafibrate 6-[1-(3,5,5,8,8-Pentamethyl-5,6,7,8-Tetrahydronaphthalen-2-Yl)Cyclopropyl]Pyridine-3-Carboxylic Acid Phthalic Acid Doconexent N-(2,2,2-TRIFLUOROETHYL)-N-{4-[2,2,2-TRIFLUORO-1-HYDROXY-1-(TRIFLUOROMETHYL)ETHYL]PHENYL}BENZENESULFONAMIDE N-(TERT-BUTYL)-3,5-DIMETHYL-N'-[(5-METHYL-2,3-DIHYDRO-1,4-BENZODIOXIN-6-YL)CARBONYL]BENZOHYDRAZIDE (2E,4E)-11-METHOXY-3,7,11-TRIMETHYLDODECA-2,4-DIENOIC ACID	Adapalene Acitretin Alitretinoin Tretinoin Tazarotene Etretinate Arotinoid acid Tamibarotene LGD-1550
Diseases			Non-small cell lung cancer Small cell lung cancer
GWAS		Wegener's granulomatosis ( 23740775)	Adventurousness ( 30643258) Airflow obstruction ( 22837378) Airway responsiveness in chronic obstructive pulmonary disease ( 25514360) Asthma ( 29273806) Blood urea nitrogen levels ( 31152163) BMI (adjusted for smoking behaviour) ( 28443625) BMI in smokers ( 28443625) Body mass index ( 28892062 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body mass index in physically inactive individuals ( 28448500) Calcium levels ( 25972035) Carotid intima media thickness in rheumatoid arthritis ( 30251476) Chronic obstructive pulmonary disease ( 28166215 30804561) Chronotype ( 30696823) Coffee consumption ( 31046077) Dental caries (decayed and filled deciduous teeth) ( 31533690) Dental caries (decayed and filled deciduous tooth surfaces) ( 31533690) Dentures ( 31235808) Dietary macronutrient intake ( 29988085) FEV1 ( 30804560) General risk tolerance (MTAG) ( 30643258) Glaucoma (primary open-angle) ( 29891935) Gout ( 22179738) Heel bone mineral density ( 30598549 28869591) Intraocular pressure ( 29785010 31959993) Low susceptibility to hepatitis C infection ( 31206233) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Macular thickness ( 30535121) Midgestational cytokine/chemokine levels (maternal genetic effect) ( 30134952) Molybdenum levels ( 26025379) Mood instability ( 31168069) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Obesity (extreme) ( 19553259) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070) Optic disc area ( 25631615 31798171 28073927) Optic disc size ( 31809533) Optic nerve head parameters (multi-trait analysis) ( 31798171) Peak expiratory flow ( 30804560) Post bronchodilator FEV1/FVC ratio ( 26634245) Pulmonary function ( 21946350) Pulmonary function (smoking interaction) ( 23284291) Pursuit maintenance gain ( 29064472) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Urinary sodium excretion ( 31409800) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		45 interacting genes: AKAP13 CACNA1B CALCOCO2 CCDC57 EXOSC8 GOLGA2 GTF2H1 KRT40 MAP4 MID2 NCOA1 NCOA3 NR0B2 NR1H2 NR1H3 NR1H4 NR1I2 NR2C2 NR2E3 NR3C1 NR4A2 NRIP1 PLSCR1 PPARD PPARG PSTPIP1 PTMS RARA RARB RARG SIAH1 SPOP TACC2 TADA3 TAF11 TFCP2 TFIP11 THRA THRB TP53BP2 TRIM27 TRIM37 UBL7 VDR ZDHHC12	20 interacting genes: ARID1A CCNH CEBPA CEBPB GATA3 HR MAP6 MEOX2 NCOA1 NCOA3 NCOR2 PNRC1 PRKD2 PSMC5 RXRA RXRB RXRG SMAD2 SMARCD3 SMARCE1
Entrez ID		6257	5915
HPRD ID		01578	07183
Ensembl ID		ENSG00000204231	ENSG00000077092
Uniprot IDs		A0A0G2JKR7 A0A0S2Z570 B7Z7J5 P28702 Q5STP9	F1D8S6 P10826 Q3SB16 Q5QHG3 Q86UC5
PDB IDs		1H9U 1UHL 5HJP 5I4V 5KYA 5KYJ	1HRA 1XAP 4DM6 4DM8 4JYG 4JYH 4JYI 5UAN 6SSQ
Enriched GO Terms of Interacting Partners?
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