GNAO1 and PTPRU

Number of citations of the paper that reports this interaction (PubMedID 10196137)
18

Data Source:
HPRD (in vitro, in vivo)

		GNAO1	PTPRU
Description		G protein subunit alpha o1	protein tyrosine phosphatase receptor type U
Image			No pdb structure
GO Annotations	Cellular Component	Heterotrimeric G-protein Complex Plasma Membrane Dendrite Cell Body	Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction
	Molecular Function	G Protein-coupled Receptor Binding GTPase Activity GTP Binding G-protein Beta/gamma-subunit Complex Binding G Protein-coupled Serotonin Receptor Binding Mu-type Opioid Receptor Binding Metal Ion Binding Corticotropin-releasing Hormone Receptor 1 Binding	Protein Tyrosine Phosphatase Activity Transmembrane Receptor Protein Tyrosine Phosphatase Activity Protein Binding Beta-catenin Binding
	Biological Process	Protein Folding Muscle Contraction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Dopamine Receptor Signaling Pathway Wnt Signaling Pathway, Calcium Modulating Pathway Locomotory Behavior Regulation Of Heart Contraction	Protein Dephosphorylation Cell Adhesion Transmembrane Receptor Protein Tyrosine Phosphatase Signaling Pathway Negative Regulation Of Cell Proliferation Cell Differentiation Negative Regulation Of Cell Migration Animal Organ Regeneration Homotypic Cell-cell Adhesion Protein Localization To Cell Surface Peptidyl-tyrosine Dephosphorylation Response To Glucocorticoid Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Cell-cell Adhesion Mediated By Cadherin
Pathways		PLC beta mediated events PLC beta mediated events G-protein activation Ca2+ pathway Ca2+ pathway Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding	Signaling by SCF-KIT
Drugs
Diseases
GWAS		Chronotype ( 30696823) Diastolic blood pressure ( 30578418) Dimensional psychopathology (Positive) ( 29496196) Metabolite levels ( 23823483) Mitochondrial DNA copy number ( 30704525) Morning person ( 30696823) Pulse pressure ( 27841878) Sleep duration (short sleep) ( 30846698)	Bipolar disorder and schizophrenia ( 20889312) Blood protein levels ( 30072576) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Pediatric non-alcoholic fatty liver disease activity score ( 23535911) Schizophrenia ( 28991256) Tourette syndrome ( 30818990)
Interacting Genes		34 interacting genes: ADORA1 ADRA2A ADRA2C CACNA1B CCR5 CRHR1 DCTN2 FFAR2 GABBR1 GNAI1 GPSM2 GRM6 HRH4 KLHL3 NGB NUCB1 OPRD1 OPRM1 PDE6G PDE6H PTPRU RGS1 RGS10 RGS14 RGS16 RGS19 RGS20 RGS4 RGS5 RGS7 RIC8A S1PR5 SCN8A TSHR	10 interacting genes: CTNNB1 EGFR ERBB2 GNAI1 GNAI2 GNAI3 GNAO1 IRS1 KIT PPFIA3
Entrez ID		2775	10076
HPRD ID		00757	03908
Ensembl ID		ENSG00000087258	ENSG00000060656
Uniprot IDs		B3KP89 P09471 Q6AWC5 Q8N6I9	Q92729
PDB IDs		6FUF 6G79 6OIK
Enriched GO Terms of Interacting Partners?
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