STK39 and SLC12A2

Number of citations of the paper that reports this interaction (PubMedID 14563843)
74

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		STK39	SLC12A2
Description		serine/threonine kinase 39	solute carrier family 12 member 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Cytoskeleton Basolateral Plasma Membrane Apical Plasma Membrane Extrinsic Component Of Membrane Intracellular Membrane-bounded Organelle	Cell Cytosol Plasma Membrane Integral Component Of Plasma Membrane Membrane Apical Plasma Membrane Extracellular Exosome Extracellular Vesicle
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Protein Kinase Binding	Protein Binding Sodium:potassium:chloride Symporter Activity Ammonium Transmembrane Transporter Activity Sodium Ion Transmembrane Transporter Activity Sodium:chloride Symporter Activity Potassium:chloride Symporter Activity Protein Kinase Binding
	Biological Process	Activation Of MAPK Activity Protein Phosphorylation Regulation Of Mitotic Cell Cycle Regulation Of Blood Pressure Positive Regulation Of T Cell Chemotaxis Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Signal Transduction By Protein Phosphorylation Signal Transduction By Trans-phosphorylation Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Positive Regulation Of Ion Transmembrane Transporter Activity Intracellular Signal Transduction Maintenance Of Lens Transparency Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway Positive Regulation Of Potassium Ion Transport Protein Autophosphorylation Regulation Of Inflammatory Response Ion Homeostasis Cellular Hypotonic Response Negative Regulation Of Pancreatic Juice Secretion Negative Regulation Of Potassium Ion Transmembrane Transporter Activity Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Creatine Transmembrane Transporter Activity Cellular Response To Chemokine Negative Regulation Of Sodium Ion Transmembrane Transporter Activity	Ion Transport Cell Volume Homeostasis Hyperosmotic Response Gamma-aminobutyric Acid Signaling Pathway Aging T Cell Chemotaxis Ammonium Transport Transepithelial Chloride Transport Sodium Ion Transmembrane Transport Positive Regulation Of Cell Volume Chloride Ion Homeostasis Potassium Ion Homeostasis Sodium Ion Homeostasis Transepithelial Ammonium Transport Ammonium Transmembrane Transport Chloride Transmembrane Transport Potassium Ion Import Across Plasma Membrane Cellular Response To Chemokine
Pathways			Cation-coupled Chloride cotransporters
Drugs			Potassium Chloride Bumetanide Quinethazone
Diseases
GWAS		Blood pressure ( 19114657) Body mass index ( 28552196 28892062) Macular thickness ( 30535121) Metabolite levels ( 23823483) Parkinson's disease ( 21292315 25064009 27182965 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Weight ( 28552196)	Beard thickness ( 26926045) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain imaging in schizophrenia (dorsolateral prefrontal cortex interaction) ( 19023125) Height ( 25282103 31562340) Ileal carcinoids ( 21139019) Red cell distribution width ( 28957414) Statin-induced myopathy ( 31220337)
Interacting Genes		14 interacting genes: AATK GSN HSPH1 MAPK14 MBP OTOF PRKCQ RELT SLC12A1 SLC12A2 SLC12A6 SPP1 TSC22D2 WNK4	3 interacting genes: COMMD1 OXSR1 STK39
Entrez ID		27347	6558
HPRD ID		09627	06775
Ensembl ID		ENSG00000198648	ENSG00000064651
Uniprot IDs		Q9UEW8	B7ZM24 P55011 Q53ZR1
PDB IDs
Enriched GO Terms of Interacting Partners?
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