BMP10 and ACVR2B

Number of citations of the paper that reports this interaction (PubMedID 22718755)
56

Data Source:
BioGRID (pull down)

		BMP10	ACVR2B
Description		bone morphogenetic protein 10	activin A receptor type 2B
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm Cell Surface Z Disc	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Protein-containing Complex Receptor Complex Activin Receptor Complex
	Molecular Function	Cytokine Activity Hormone Activity Protein Binding Growth Factor Activity Telethonin Binding Receptor Serine/threonine Kinase Binding	Protein Serine/threonine Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Activin Receptor Activity, Type II Activin-activated Receptor Activity Growth Factor Binding Metal Ion Binding Activin Binding
	Biological Process	Cell Adhesion Adult Heart Development Negative Regulation Of Endothelial Cell Migration Positive Regulation Of Cardiac Muscle Hypertrophy Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Negative Regulation Of Cell Growth Negative Regulation Of Cell Migration BMP Signaling Pathway Activin Receptor Signaling Pathway Sarcomere Organization Positive Regulation Of Transcription, DNA-templated Atrial Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Tissue Morphogenesis Ventricular Cardiac Muscle Cell Development Regulation Of Cardiac Muscle Contraction Cardiac Muscle Cell Proliferation Positive Regulation Of Cardiac Muscle Cell Proliferation Positive Regulation Of Sarcomere Organization Heart Trabecula Formation Pathway-restricted SMAD Protein Phosphorylation SMAD Protein Signal Transduction Positive Regulation Of Cartilage Development Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Positive Regulation Of Cell Proliferation Involved In Heart Morphogenesis	Negative Regulation Of Transcription By RNA Polymerase II Gastrulation With Mouth Forming Second Kidney Development Lymphangiogenesis Blood Vessel Remodeling Regulation Of Transcription, DNA-templated Protein Phosphorylation Signal Transduction Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Determination Of Left/right Symmetry Mesoderm Development Heart Development Response To Glucose Post-embryonic Development Anterior/posterior Pattern Specification Insulin Secretion Lung Development Positive Regulation Of Bone Mineralization BMP Signaling Pathway Pancreas Development Activation Of Protein Kinase Activity Activin Receptor Signaling Pathway Positive Regulation Of Activin Receptor Signaling Pathway Organ Growth Odontogenesis Of Dentin-containing Tooth Positive Regulation Of Osteoblast Differentiation Embryonic Foregut Morphogenesis Skeletal System Morphogenesis Roof Of Mouth Development Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Retina Vasculature Development In Camera-type Eye Cellular Response To Growth Factor Stimulus Negative Regulation Of Cold-induced Thermogenesis
Pathways		Signaling by BMP Molecules associated with elastic fibres	Signaling by NODAL Regulation of signaling by NODAL Signaling by Activin Signaling by Activin Signaling by BMP
Drugs
Diseases			Heterotaxy; Situs ambiguus
GWAS			Bitter beverage consumption ( 31046077) Estimated glomerular filtration rate ( 31152163 31015462) P wave duration ( 24850809)
Interacting Genes		4 interacting genes: ACVR2A ACVR2B BMPR2 SERINC3	21 interacting genes: ACVR1B BMP10 BMP2 BMP7 ERBIN FBXO7 GDF11 GDF2 GDF5 IGSF1 INHBA INHBB INHBC MSTN NODAL SNX1 SNX2 SNX6 SYNJ2BP TDGF1 TGFBRAP1
Entrez ID		27302	93
HPRD ID		09788	04106
Ensembl ID		ENSG00000163217	ENSG00000114739
Uniprot IDs		O95393	Q13705
PDB IDs			2H62 2QLU 4FAO 5NGV 5NHR
Enriched GO Terms of Interacting Partners?
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