KLHL20 and ARHGEF12

Number of citations of the paper that reports this interaction (PubMedID 21670212)
16

Data Source:
BioGRID (enzymatic study)

		KLHL20	ARHGEF12
Description		kelch like family member 20	Rho guanine nucleotide exchange factor 12
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Actin Cytoskeleton PML Body Axon Dendrite Cul3-RING Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm	Cytoplasm Cytosol Membrane Extracellular Exosome
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding Interferon-gamma Binding	G Protein-coupled Receptor Binding Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding
	Biological Process	Golgi To Endosome Transport Cytoskeleton Organization Protein Transport Protein Ubiquitination Response To Interferon-alpha Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Protein K33-linked Ubiquitination	G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse
Drugs
Diseases
GWAS		Feeling miserable ( 29500382)	Attention deficit hyperactivity disorder symptom score ( 27663945) Coronary artery disease ( 29212778 30104761) Glaucoma ( 31959993 30054594) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 29891935 25173105) Height ( 31562340) Intraocular pressure ( 29617998 25637523 31798171 29785010 31959993 30054594 28073927 29235454)
Interacting Genes		19 interacting genes: ACTA1 ARHGEF12 CEP126 CORO7 CRK CRMP1 DAPK1 ECT2 EPAS1 ERG28 GBP2 IVNS1ABP LRIF1 LUC7L2 MTNR1A PIN1 PML PRMT6 SUV39H1	18 interacting genes: ABCA1 CD44 CLK1 CUL3 EGFR GIPC1 GNA12 GNA13 IGF1R KLHL20 LPAR1 LPAR2 PLXNB1 PLXNB2 PTPRF RHOA RPS6KA1 TEC
Entrez ID		27252	23365
HPRD ID		13918	09207
Ensembl ID		ENSG00000076321	ENSG00000196914
Uniprot IDs		Q9Y2M5	B4E2K6 E9PMR6 Q9NZN5
PDB IDs		5YQ4 6GY5	1TXD 1X86 2OMJ 2OS6
Enriched GO Terms of Interacting Partners?
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