KLHL20 and ECT2

Number of citations of the paper that reports this interaction (PubMedID 14668487)
15

Data Source:
HPRD (two hybrid)

		KLHL20	ECT2
Description		kelch like family member 20	epithelial cell transforming 2
Image
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Trans-Golgi Network Cytosol Actin Cytoskeleton PML Body Axon Dendrite Cul3-RING Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm	Nucleus Nucleoplasm Cytoplasm Cytosol Cell-cell Junction Bicellular Tight Junction Nuclear Body Midbody Cleavage Furrow Mitotic Spindle Centralspindlin Complex
	Molecular Function	Actin Binding Ubiquitin-protein Transferase Activity Protein Binding Interferon-gamma Binding	Rho Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Protein Homodimerization Activity
	Biological Process	Golgi To Endosome Transport Cytoskeleton Organization Protein Transport Protein Ubiquitination Response To Interferon-alpha Negative Regulation Of Apoptotic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Post-translational Protein Modification Protein K33-linked Ubiquitination	Mitotic Cytokinesis Cell Morphogenesis G Protein-coupled Receptor Signaling Pathway Protein Transport Activation Of Protein Kinase Activity Positive Regulation Of Cytokinesis Intracellular Signal Transduction Positive Regulation Of Protein Import Into Nucleus Positive Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of GTPase Activity Positive Regulation Of Neuron Differentiation Regulation Of Protein Kinase Activity Regulation Of Small GTPase Mediated Signal Transduction Protein Homooligomerization Regulation Of Attachment Of Spindle Microtubules To Kinetochore Cellular Response To Hydrogen Peroxide Bicellular Tight Junction Assembly Cellular Response To Calcium Ion Cellular Response To Ionizing Radiation Activation Of GTPase Activity Regulation Of Cytokinesis, Actomyosin Contractile Ring Assembly
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	NRAGE signals death through JNK Rho GTPase cycle G alpha (12/13) signalling events
Drugs
Diseases
GWAS		Feeling miserable ( 29500382)	Obesity-related traits ( 23251661)
Interacting Genes		19 interacting genes: ACTA1 ARHGEF12 CEP126 CORO7 CRK CRMP1 DAPK1 ECT2 EPAS1 ERG28 GBP2 IVNS1ABP LRIF1 LUC7L2 MTNR1A PIN1 PML PRMT6 SUV39H1	37 interacting genes: ABR C2orf42 CCDC91 CD19 CDK1 CHST10 CSTB EIF4A2 EIF5B ELOC ERAL1 F2RL2 FANCM GGN ILVBL KLHL20 MBD1 MT-CO2 MT2A NOMO1 NPC2 OOSP2 OTUB1 PARD6A PCOLCE PLK1 POMP PSMA6 RACGAP1 RHOG RPS20 SNRNP200 SPATA22 SRPK2 THAP11 UBB VDAC2
Entrez ID		27252	1894
HPRD ID		13918	11860
Ensembl ID		ENSG00000076321	ENSG00000114346
Uniprot IDs		Q9Y2M5	Q9H8V3
PDB IDs		5YQ4 6GY5	3L46 4N40
Enriched GO Terms of Interacting Partners?
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