SNX5 and APPBP2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		SNX5	APPBP2
Description		sorting nexin 5	amyloid beta precursor protein binding protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Phagocytic Cup Endosome Cytosol Brush Border Cytoplasmic Vesicle Membrane Retromer Complex Retromer, Tubulation Complex Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Extrinsic Component Of Endosome Membrane Early Endosome Membrane Intracellular Membrane-bounded Organelle Perinuclear Region Of Cytoplasm Macropinocytic Cup Tubular Endosome	Nucleus Cytoplasm Microtubule Microtubule Associated Complex Cytoplasmic Vesicle Membrane
	Molecular Function	Protein Binding Phosphatidylinositol-5-phosphate Binding D1 Dopamine Receptor Binding Dynactin Binding Phosphatidylinositol Binding Cadherin Binding Protein Heterodimerization Activity Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding	Microtubule Motor Activity Protein Binding
	Biological Process	Intracellular Protein Transport Pinocytosis Epidermal Growth Factor Catabolic Process Regulation Of Macroautophagy Positive Regulation Of Renal Sodium Excretion Retrograde Transport, Endosome To Golgi Negative Regulation Of Blood Pressure Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Insulin Receptor Signaling Pathway	Intracellular Protein Transport Intracellular Transport
Pathways		Golgi Associated Vesicle Biogenesis
Drugs
Diseases
GWAS		Cholesterol, total ( 25961943) LDL cholesterol ( 24097068 25961943) LDL cholesterol levels ( 28334899 30698716) LDL cholesterol levels in current drinkers ( 30698716) LDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) LDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716)	Waist-hip ratio ( 28552196)
Interacting Genes		15 interacting genes: APPBP2 AQP2 CDC37 CLTC CLTCL1 DNAJB11 FANCA HGS HMOX2 ITSN1 MESD MIB1 PFDN1 PRKRA SNX2	81 interacting genes: - AHCY AIM2 AK3 ANKRD10 APP AR ARMCX5 C1orf50 C6orf226 CALM3 CCDC85C CCNL1 CDK16 CHMP5 CIBAR1 CLCN1 CNTFR COL24A1 CORO2B CREB3 CSNK1G2 CTC1 CYBA DCD DHRS2 DPEP1 EID3 ERO1A FAM107A FSTL1 FXYD7 GALNT3 GCSAM GP9 GSTP1 H2AC15 HIPK4 HSPA4 KIF6 KLF11 KLHL35 LANCL2 LONRF3 LUC7L2 LUZP4 MFSD3 MLLT3 MUL1 NFYA NPRL3 PCSK5 PI4KAP2 PPP1R8 PRKAA2 PRKACB PYROXD2 RASSF5 RNF128 RNF34 RRS1 SELENOI SELENOV SLC22A6 SLC25A23 SNX5 ST8SIA5 SYNRG SYT11 TAF11 TAFA4 TBL3 TCF25 UBE2R2 UGGT2 WAS WDR24 WNT5B ZC3H10 ZCCHC12 ZNF747
Entrez ID		27131	10513
HPRD ID		10439	05616
Ensembl ID		ENSG00000089006	ENSG00000062725
Uniprot IDs		Q6P5V6 Q9Y5X3	A0A024QZ47 Q92624
PDB IDs		1SYS 5TGH 5TGI 5TGJ 5WY2 6N5X 6N5Y 6N5Z
Enriched GO Terms of Interacting Partners?
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